A Study of serum aluminium levels in patients of Chronic Renal Failure on haemodialysis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Chronic Kidney Disease (CKD) is a clinical condition in which there is an irreversible loss of endogenous renal function, to render the patient permanently dependent upon renal replacement therapy. Even optimal dialysis therapy is not a remedy. There are abnormalities that develop after initiation of dialysis therapy like aluminium overload. The clinical consequence of aluminium overload includes a neurologic syndrome. This study was taken to find out aluminium concentrations in blood of CKD patients and to identify clinical co-relation with aluminium concentration on 25 patients (16 males and 9 females) of CKD undergoing hemodialysis at Bombay Hospital Institute of Medical Sciences, Mumbai. They were divided into 3 groups on the basis of duration of maintenance hemodialysis. Group I: > 1 year, Group II: 6 months to 1 year and Group III: < 6 months. For quantification of aluminium content, electro thermal atomic absorption spectrometry method was used and done at serology laboratory. Blood aluminium level in 25 patients was in range of 22.7 to 150.50 µg/L. (in group I were in range of 22.70 to 119.60 µg/L, in group II were in range of 23.70 to 150.50µg/L and in group III, it was in range of 47.90 to 121.40µg/L). Out of 25 patients, 11 patients had symptoms and aluminium blood levels ranging from 22.70 to 121.4090µg/L. In asymptomatic patients levels ranged from 23.790µg/L to 150.590µg/L. There was no significant relation of blood aluminium levels and symptoms (p=0.220). We conclude that the blood aluminium levels were high, which could be due to use of aluminum utensils and/or alternative medicine. They will need counseling regarding stopping of using alternative medicine and aluminium utensils. Keywords:Aluminium, Chronic kidney disease, Dialysis
Authors and Affiliations
Pankaj Surendra Patil, Rohini V. Chowgule
Keywords
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