A study of serum amylase levels in acute organophosphorous poisoning at Government Dharmapuri Medical College Hospital, Dharmapuri
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 9
Abstract
Introduction: In India, OP compounds cause more self-poisoning deaths in southern and central India. In Northern India, aluminum phosphide causes most deaths with a fatality ratio. Poisoning due to occupational exposure, accounted for about one fifth of the incidents, with a fatality ratio of less than 1%. More than 90% of the non-occupational incidents were suicidal, with a fatality rate more than 10% and the majority of the subjects are young males. Accidental exposures accounted for 8-10% of the incidents and homicidal use (less than 1%) were other forms of poisoning. The reported overall mortality following OP insecticide poisoning varies from 4-30% in different countries and institutions. Aim: To estimate serum Amylase levels in acute organophosphorus compound poisoning and the find out the clinical outcomes. Materials and methods: The study was conducted in Government Dharmapuri Medical College Hospital, Dharmapuri. Study duration was from January 2017 to June 2017. Of a total of 145 patients with organophosphorus compound poisoning admitted to the hospital during the study period, 40 were included in the study. 10 healthy (age matched) individuals were kept as a control. Biochemical evaluation which includes Serum Amylase Blood glucose, urea, creatinine, and Liver function tests were analyzed and matched among the two groups. Results: The biochemical results have not shown much variation from the normal levels in our study. In the study, the Amylase levels were significantly elevated at the time of admission (185.2 U/L) and have shown a gradual remission with proper treatment. The mean Amylase level in severely poisoned patients was 297.7 U/L which was significantly (P < 0.01) higher than the healthy control group. On comparing the Amylase levels in first 24 hours against control, the variations were considered to be significant (P < 0.01). Conclusion: From the observation we made, it could be suggested that OP pesticide poisoning is a serious condition that needs rapid diagnosis and treatment. The mean Amylase level in first 24 hours of OP poisoning was 154 U/L which is significantly higher than the control groups.
Authors and Affiliations
P. Elango, G. Indumathi
Keywords
Related Articles
- EP ID EP409863
- DOI -
- Views 144
- Downloads 0
A prospective single blinded randomized study to assess post operative analgesia using ultrasound guided transverse abdominis plane block for laparoscopic appendectomy
Introduction: Pain is one of the most important factors that is responsible for many adverse outcomes during surgery and in postoperative period. Effective pain control can also facilitate rehabilitation and accelerate r...
Oral manifestations associated with neutrophil deficiency and neutrophil disorders: A review
The immune system evolved to protect multicellular organisms from pathogens. It defends the body against invaders, and generates an enormous variety of cells and molecules capable of specifically recognizing and eliminat...
Clinical Profile and Outcome of Acute Poisoning in Children Less than 12 years of Age
Background: Poisoning among children is one of the common medical emergencies encountered in Pediatric practice. Rapid industrialization and exposure to harmful chemicals, introduction of newer range of drugs have widene...
Thyrotoxic cardiomyopathy - A case report
Cardiomyopathy is an uncommon presentation in hyperthyroid patients. There are very few case reports of thyrotoxic cardiomyopathy. The mechanism due to which cardiomyopathy occurs in hyperthyroid patients is not very wel...
Association between bacterial vaginosis and preterm labor and high risk cases for preterm labor
Background: Preterm delivery is a major contributor to neonatal morbidity and mortality and its prevention assumed special importance in the practice of obstetrics. It is well known that the risk of neonatal death increa...