A Study of Serum Magnesium, Calcium and Phosphorus in Hypothyroidism
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 2
Abstract
Introduction: Hypothyroidism, the commonest form of hormonal dysfunction, is due to thyroid hormone deficiency or its impaired activity. Various electrolyte disturbances in association with hypothyroidism were observed in many studies. The role of thyroid hormones on mineral metabolism is not well understood and the underlying mechanism too. The present study was undertaken to assess and analyze the alterations in the levels of serum calcium, magnesium and phosphorous and their relation with T3, T4 and TSH in hypothyroid state. Materials and Methods: A case control study was taken up on 40 normal healthy subjects and 40 subjects with thyroid hormone deficiency. Blood sample for analysis was collected from all the subjects. Serum T3, T4, TSH, magnesium, calcium and phosphorous were estimated in all the subjects. Results: A significant hypocalcemia was observed among cases compared to controls (p<0.0001).Serum phosphorous (p<0.0001) and magnesium(p<0.0001) were significantly increased among cases compared to controls. Conclusion: The present study indicated significant effect of thyroid hormones on these minerals. This study concludes that serum phosphorous and magnesium levels were high whereas serum calcium level was low in hypothyroidism when compared to normal subjects. A regular follow up of these serum minerals should be done in thyroid hormone deficiency which would be of great help in its management.
Authors and Affiliations
D. Sridevi, Amrut A Dambal, Sidrah . , Anila Sushma Challa, Samata K. Padaki
Association of 25 OH-Vitamin D and hs-CRPin adults with Essential Hypertension
Essential hypertensionis a typical example of complex, multifactorial trait and a well studied risk factor for cardiovascular disease. hs-CRP is well known marker of inflammation resulting in atherosclerosis and cardiova...
Qualitative chemical analysis and incidence of renal stone disease in rural population of South Solapur, Maharashtra
Background: There are many reports regarding renal stone disease, which have documented that it is a complex disease process and widely distributed in developed as well as developing world with varied chemical constituti...
A study to assess the relation between severity of hypothyroidism and Lipid parameters
Background: Hypothyroidism is associated with dyslipidemia. The present study was conducted to assess the relation between hypothyroidism and lipid parameters and lipid ratios. It is also done to assess the severity of h...
Evaluation of coagulation profile in patients suffering with type-2 diabetes mellitus: A hospital based prospective study
Introduction: T2DM and its complications develop due to uncontrolled plasma glucose levels for long time. Long term hyperglycemia will cause glycation of various tissue proteins. It also affects the coagulation process a...
Relation between serum electrolytes & serum creatinine levels in diabetes mellitus
Aim: Diabetes mellitus with altered renal function is associated with the disturbed pattern in serum electrolytes. There arises a need to evaluate the serum electrolytes in diabetic patients according to the stage of the...