A study of serum uric acid in nonalcoholic fatty liver disease patients
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 12
Abstract
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease and serum uric acid is observed to be significantly elevated in NAFLD patients. Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Nonalcoholic fatty liver disease is now considered a hepatic manifestation of insulin resistance. However association between uric acid and NAFLD is known very little only. Aim: This study is aimed at the correlation between high serum uric acid levels and nonalcoholic fatty liver disease. Material and methods: This was an observational cross sectional study conducted in patients admitted to the General Medicine wards and medical OPD with clinical features suggestive of NAFLD. All patients with evidence of NAFLD in clinical features and imaging were taken up for the study based on strict inclusion and exclusion criteria and their serum uric acid was done. Patients details regarding various risk factors and clinical features were recorded on a well thought out and carefully prepared proforma. The data was analyzed and the results were compared with other available similar studies. Results: The average age of patients in this study was 53.84 years. Of the 50 patients studied, 48 % were males and 52 % were females. Most of the patients were above 40 years of age. Hyperuricemia was found to be one of the most important risk factor. NAFLD patients with hyperuricaemia have considerable risk of progression of their fatty liver disease severity. Patients with fatty liver and its association with increased serum uric acid was analyzed. These results were compared with various other studies. The results were comparable between these studies. Conclusion: Uric acid is an old molecule with many new applications and it has also been studied in various metabolic diseases, cardiovascular diseases and chronic kidney disease. In this study it has been found that increased serum uric acid has a significant correlation with NAFLD, obesity, hypertension, increased body mass index (BMI), triglyceride and increased cholesterol levels in blood.
Authors and Affiliations
Shivani Jindal, Harsh Bala Gupta, Ramesh Chander Jaswant Singh , Dr. N. S. Neki.
Keywords
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- EP ID EP548966
- DOI 10.22192/ijcrms.2018.04.12.010
- Views 230
- Downloads 0
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