A Study of Serum Uric Acid Levels in Acute Stroke Patients
Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 8
Abstract
Abstract:Hyperuricemia is commonly seen in subjects with cardiovascular disease and it one of the risk factor for morbidity and mortality with cardiovascular diseases. Uric acid is a product of synthesis from nucleic acids, amino acids, and Kreb's Cycle. Uric acid is biologically active and can stimulate oxidative stress and endothelial dysfunctions, inflammation, and vasoconstriction. The present study tries to evaluate the levels of uric acid in patients suffering from an acute ischemic stroke in comparison with normal subjects. Methods: This prospective cross-sectional study was conducted in the Departments of General Medicine and Biochemistry Prathima Institute of Medical Sciences, Naganoor, Karimnagar. A total of 80 subjects were included in the study. They were divided into two groups. Group I [cases] (n=40) consisted of patients reporting to the Emergency Department within 24 hours of onset of symptoms of stroke. The Group II [controls] (n=40) were the age and sex-matched patients attending the General Medicine OPD with minor complaints. Results: The mean age of Group I (n=40) was 61.42 ± 2.99 years and Group II was (n=40) 48.9 ± 4.53 years. The numbers of the male in Group I were 29 and female were 11 and in control, Group was 20 male and female each. The blood urea Group I was 38.7 ± 5.59 mg/dl and in Group II 30.12 ± 8.86 the p values were not found to be significant. The serum creatinine was 1.13 ± 6.61 in group I and in Group II was 0.91± 0.17 mg/dl and the p values were found to be significant. The uric acid levels were 7.32 ± 2.25 mg/dl in group II and 4.95 ± 1.5 mg/dl in Group I the values were found to be significant. Conclusion: Within the limitations of the present study it can be concluded that serum uric acid levels are significantly associated with ischemic stroke in this group of the population. The other important factors for the risk of ischemic strokes include Hypertension and Diabetes mellitus. There is growing evidence that uric acid may play a key role in the development and progression of cardiovascular diseases. Keywords: Serum Uric Acid (SUA), Acute Ischemic stroke.
Authors and Affiliations
Sujana Nidumuru
Keywords
Related Articles
- EP ID EP399869
- DOI -
- Views 84
- Downloads 0
A perplexing fibro-osseous entity: Central ossifying fibroma of maxilla
Abstract: Central ossifying fibroma is a rare slow growing destructive benign fibro-osseous tumor. It is typically found in craniofacial bones, frequently involving the mandible. The present case showed maxillary involve...
Factors Affecting Outcomes of IVF in Unexplained Infertility
Unexplained infertility refers to the absence of a definable cause for infertility despite a thorough evaluation. Subtle abnormalities like mild endometriosis, minor tubal dysfunction as evidenced by presence of perituba...
The Gene Therapy – Exploring the Challenges…
Abstract:Genes are the smallest functional units of the genetic system, which control the development and function of all organisms. A gene is a linear sequence of DNA that codes for a particular protein. Gene therapy is...
An Overlooked Complication of Diabetes: Diabetic Hand Wounds
Abstract:Diabetes Mellitus is the most common endocrinological condition. We can see complications as a result of the changes in microcirculation and tissue collagen structure.In our study; we aimed to discuss the clinic...
To Study the Survival Rate of Patients Who Will Be Admitted Consumption of Aluminium Phosphide
Abstract:‘Poison’– The term first appeared in English Literature around the year 1230. It refers to a substance with an inherent property of being harmful to life or health. The earliest used poison, used in wars and off...