A Study of Serum Vitamin D Levels in Newly Diagnosed Pulmonary Tuberculosis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Background: Vitamin D was used in tuberculosis management in the pre-antibiotic era. Vitamin D deficiency has been implicated in activation of TB. A meta-analysis published has shown the association of vitamin D deficiency with two-fold higher risk of active TB and certain studies had also demonstrated that vitamin D supplementation in TB patients is associated with faster clinical and radiological improvement and sputum smear conversion. Aim: To assess the serum vitamin D levels among the patients with pulmonary tuberculosis and its association with the severity of the disease. Methodology: A cross-sectional study was conducted for a period of one year in Government medical college hospital, Salem. A total of 300 patients with pulmonary tuberculosis confirmed by sputum AFB were included in the study. The vitamin D status of study participants was interpreted based on the serum 25- (OH) Vitamin D concentration following the manufacturer’s instructions as deficient (<20 ng/ml), insufficient (20–29 ng/ml), sufficient (30–100 ng/ml) and potential toxicity (>100 ng/ml). Results: Vitamin D levels were found to be normal in 34% of the subjects and it was insufficient in 11% and found to be deficit in 55% of the study subjects. Multi-logistic regression analysis was applied to identify the factors influencing deficiency of vitamin D among the patients with tuberculosis among males and females. It was proved that age more than 30 years , female gender, sputum results showing 1+ or more, BMI <18.5 and patients with various co-morbidities found to have statistical significant association with reduction in the vitamin D levels among patients with tuberculosis. Conclusion: Considering the high prevalence of vitamin D deficiency, the present study implicates that further follow-up studies are warranted to determine whether vitamin D supplementation can have a role in the prevention and treatment of tuberculosis.
Authors and Affiliations
Dr M Kumar Raja
Keywords
Related Articles
- EP ID EP501067
- DOI -
- Views 63
- Downloads 0
Prevalence of Tobacco Consumption among Urban Tribals of Mandla District (M.P)
Introduction: Tobacco is one of the most common abuse substances all over the world. Tobacco leads to disease and disability and harms nearly every organ of the body. According to the World Health Organization (WHO), nea...
Spina Bifida in a Newborn – A Case Report
Spina bifida is a neural tube defect with average incidence of 1-2 cases per 1000 population with female to male ratio of 1.2:1.These defects occur as a result to a teratogenic process that causes failed closure and abno...
Fibro-osseous Lesions of Cranio-facial region: An Institutional Study
Introduction: Fibro-osseous lesions are a diverse group of bone disorders with fibrous dysplasia and ossifying fibroma as the major entities. They are extremely slow growing tumors that share overlapping clinical, radiog...
Multidrug Resistant Organisms in Diabetic Foot Ulcers-Analysis of Risk Factors and Clinical Outcome
Background: Diabetes Mellitus is one of the most important health problem in the world. Foot infection is a common sequelae of diabetes, which once established progressively worsens and become more difficult to treat and...
To Study Effectiveness of Nasal Prong and Nasal Mask in Nasal Continuous Positive Airway Pressure in Preterm Neonates with Respiratory Distress
Objective: To analyse whether nasal continuous positive airway pressure (NCPAP) given with nasal prongs compared with nasal mask reduces the rate of intubation and mechanical ventilation in preterm infants within 72 hour...