A Study of Serum Vitamin D Levels in Newly Diagnosed Pulmonary Tuberculosis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Background: Vitamin D was used in tuberculosis management in the pre-antibiotic era. Vitamin D deficiency has been implicated in activation of TB. A meta-analysis published has shown the association of vitamin D deficiency with two-fold higher risk of active TB and certain studies had also demonstrated that vitamin D supplementation in TB patients is associated with faster clinical and radiological improvement and sputum smear conversion. Aim: To assess the serum vitamin D levels among the patients with pulmonary tuberculosis and its association with the severity of the disease. Methodology: A cross-sectional study was conducted for a period of one year in Government medical college hospital, Salem. A total of 300 patients with pulmonary tuberculosis confirmed by sputum AFB were included in the study. The vitamin D status of study participants was interpreted based on the serum 25- (OH) Vitamin D concentration following the manufacturer’s instructions as deficient (<20 ng/ml), insufficient (20–29 ng/ml), sufficient (30–100 ng/ml) and potential toxicity (>100 ng/ml). Results: Vitamin D levels were found to be normal in 34% of the subjects and it was insufficient in 11% and found to be deficit in 55% of the study subjects. Multi-logistic regression analysis was applied to identify the factors influencing deficiency of vitamin D among the patients with tuberculosis among males and females. It was proved that age more than 30 years , female gender, sputum results showing 1+ or more, BMI <18.5 and patients with various co-morbidities found to have statistical significant association with reduction in the vitamin D levels among patients with tuberculosis. Conclusion: Considering the high prevalence of vitamin D deficiency, the present study implicates that further follow-up studies are warranted to determine whether vitamin D supplementation can have a role in the prevention and treatment of tuberculosis.
Authors and Affiliations
Dr M Kumar Raja
Keywords
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