A Study of Synergistic Antibacterial Activity of Silver Nanoparticles with Antibiotics against Multi-Drug Resistant Pseudomonas aeruginosa in Intensive Care Units of a Tertiary Care Hospital
Journal Title: International Journal of Current Microbiology and Applied Sciences (IJCMAS) - Year 2018, Vol 7, Issue 11
Abstract
Evolution of multi drug resistant isolates has become rampant in today’s world. The credit of this goes to the incomplete dosage and irrational use of antibiotics. The human brains are now in search of alternate methods. Use of Silver nanoparticles is one amongst them. In the following study, 50 multi-drug resistant clinical isolates of P. aeruginosa acquired from the intensive care units were tested with antibiotics, AgNps and AgNp-antibiotic conjugates. The conjugates were prepared by impregnating 30 µl of AgNps in sterile plain disks and the antibiotic disks separately. The antibiotics tested were Ciprofloxacin, Amikacin, Ceftazidime and Piperacillin-Tazobactam. Maximum number of isolates showed zone enhancement with both AgNp and AgNp – antibiotic conjugates. Fewer numbers of isolates that did not show enhancement may have different mechanisms of resistance like point mutations. Nanoparticles are not able to overcome point mutations. Thus, Nanotechnology has served to be a boon to overcome the massive war against Multidrug resistant isolates.
Authors and Affiliations
Komal Mirlekar, Anjali Swami, Sujata Baveja, Shanta Shubhra Das
Keywords
Related Articles
- EP ID EP583115
- DOI 10.20546/ijcmas.2018.711.012
- Views 40
- Downloads 0
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