A study of thyroid function in children with Beta thalassemia major.
Journal Title: BJKines-National Journal of Basic & Applied Science - Year 2018, Vol 10, Issue 1
Abstract
One of the most common endocrine disorder in beta-thalassemia major is Hypothyroidism. The aim of this study was to evaluate thyroid function status in β-thalassemia major patients above the age of 7 years. Materials & Methods: This cross sectional study was carried out on beta thalassemia major patients registered at Thalassemia Centre of civil hospital, Ahmedabad. A questionnaire was filled out to evaluate the demographic information, information about transfusions and chelation therapy. Growth parameters were evaluated. We assessed serum fT4, fT3 and TSH levels in all patients above 7 years with consent and those who were found to have hypothyroidism were subjected to further management. Results: 97 patients (7-14 years age) (46 males and 51 females) were enrolled in this study. Hypothyroidism was found in 18 patients (15.3%); 5 patients with primary overt Hypothyroidism, and 13 patients with subclinical primary Hypothyroidism were detected. Out of 18patients, 8 patients were male and 10 patients were female.11 patients were above 11 year of age and 6 patients between 9-11 year of age and 1 patient below 9 year. Short stature was found in 62(63.9%) patients. Correlation of Hypothyroidism with serum ferritin level and short stature was significant. Regular transfusion and chelation therapy were associated with ferritin level. Conclusion: High prevalence of Hypothyroidism among thalassemia patients signifies the importance of regular screening for evaluation of endocrine function in these patients, especially after 7 year of age and when ferritin levels are high.
Authors and Affiliations
Dr. Gargi PathaK, Dr. Anuya Chauhan, Dr. Jay Badiyani
Keywords
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