A study of total and differential leucocyte count with severity of lung disease in pulmonary tuberculosis
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 8
Abstract
Background: Hematological investigation and basic biochemical tests are routinely, or rather invariably, carried out during the work up of a case of tuberculosis. Studies have shown that hematological and biochemical abnormalities in tuberculosis are common. This cross sectional study was carried out to identify the presenting laboratory features that may help differentiate a freshly diagnosed and uncomplicated case of tuberculosis from other diseases and to correlate it with the severity of pulmonary tuberculosis. Material and Methods: The study subjects included 100 patients above 12 years of age without HIV co-infection of newly diagnosed cases of pulmonary and extrapulmonary tuberculosis diagnosed. The DLC and platelet counts were further confirmed with Feild or Leishman’s stains using EDTA anticoagulated blood. Initially, a slide was made by spreading a drop of blood on the slide to make a film of at least 3 cm in length. Thickness such that there was some overlap of red cells throughout much of the film’s length. Results: Out of the 100 cases of tuberculosis collected from our hospital, 55 patients were PTB, and 45 were of extra-pulmonary tuberculosis. The incidence of leucocytosis increased from 1 in 11 cases in mild, 9 in 23 with moderate and 11 in 21 with severe lung involvement. However, in all only 21 out of 55 cases of pulmonary TB showed mild leucocytosis. Lymphocytosis was seen in 2 cases of mild and 3 cases of moderate lung involvement. Increasing lymphopenia was seen with increasing severity of lung parenchymal involvement. 2 cases of eosinophilia were seen. Discussion: these parameters can be used as indicators in the assessment of response to chemotherapy. In view of the varied haematological abnormalities observed in patients with tuberculosis in patients of this geographical location. We suggest the differential diagnosis of tuberculosis should be entertained in patients with varied haematological disorders
Authors and Affiliations
Laxmikant Chavan, Saket Kumar Mandal, Raju M Jotkar
Keywords
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