Abstract

Objectives: To study the role of β – hCG in pathogenesis of preeclampsia and its association with severity of preeclampsia. Materials and Methods: The prospective randomized study was conducted on 500 pregnant women of gestational pregnancy between 12 - 24 weeks with singleton pregnancy. According to American college of obstetrics and gynecology [ACOG, 2013], patients were classified into three groups, normal (N=250), mild pre-eclampsia (N=200) and severe pre-clampsia (N=50). Quantitative determination of hCG by sandwich enzyme immunoassay. Results were expressed as mean ±standard error. The significance of the difference between the values from different groups was determined by ANOVA. A level of P < 0.05 was defined as statistically significant. Results: Systolic and diastolic blood pressures were significantly increased in mild and severe (P < 0.001) pre-eclampsia women. The levels of urea, creatinine and uric acid were significantly increased in severe pre-eclampsia women. The serum level of maternal β-hCG was markedly raised in pre-eclampsia in comparison to controlled and parallel with the severity of pre-eclampsia. The maternal serum level of β-hCG plays one of the important role in pathogenesis of pre-eclampsia and its severity.

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