A study on adenosine deaminase activity in pleural effusion of tuberculous and non tuberculous origin
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Accumulation of fluid in the pleural space that exceeds the physiological amount is defined as pleural effusion Pleural effusion can be either transudative or exudative The exudative pleural effusion is predominantly observed in tuberculosis Adenosine deaminase ADA level remains high in disorders where cellular immunity is stimulated Tuberculosis is one such diseaseMaterials and Methods The cases were classified as two groups 30 patients of tubercular pleural effusion were enrolled in Group I and 30 patients of nontubercular pleural effusion were Group II In nontubercular pleural effusion 6 cases were malignant effusions 12 cases were parapneumonic effusions and 12 cases were transudative effusions which include 4 cases of congestive cardiac failure 4 cases of nephrotic syndrome and 4cases of hepatic cirrhosis The following biochemical parameters in pleural fluid were estimated They are Glucose Protein and Adenosine deaminaseResults In this study mean pleural fluid glucose level was significantly higher in transudative when compared to exudative pleural effusions In exudative pleural effusions mean pleural fluid protein level was increased significantly as compared to transudative pleural effusions The activity of ADA in tubercular effusion was significantly higher when compared to non tubercular pleural effusions of different etiology such as malignant parapneumonic and transudativeConclusion The assessment of ADA act as better marker for identifying tuberculosis than the traditional markersKeywords Pleural effusion Exudative Transudative Tuberculosis Adenosine deaminase
Authors and Affiliations
D S. S. K. Raju, S J. Basha, M Anil Kumar
Keywords
Related Articles
- EP ID EP475435
- DOI 10.18231/2394-6377.2018.0122
- Views 67
- Downloads 0
Xanthine oxidase -oxidase stress marker in acute MI patient: a study at a teaching hospital in Telangana
Introduction: Despite impressive strides in diagnosis and management over the past three decades, acute myocardial infarction (AMI) continues to be a major public health problem in the industrialized world and is becomin...
Serum ferritin in pre-diabetes & diabetes mellitus type 2 and its relationship with glycemic status
Introduction: Emerging scientific evidence suggests an increased prevalence of elevated serum ferritin levels in diabetes mellitus type 2. Serum ferritin, being a reliable marker of body iron stores, have been related to...
Association of total plasma homocysteine levels in hypothyroid individuals
One of the major complication of hypothyroidism is atherosclerosis and cardiovascular disease. Hyperhomocysteinemia is an important and independent risk factor for atherosclerosis. Hypothyroidism decreases hepatic levels...
Role of serum magnesium in diabetes mellitus - A case control study
Introduction Diabetes mellitus characterized by high glycemic levels is routinely associated with many mineral abnormalities The purpose of this study was to evaluate the levels of serum magnesium among subjects with dia...
Assessment of metabolic (Adiponectin, Leptin) and inflammatory markers (TNF-α, hs-CRP & IFN-γ) in Pulmonary Tuberculosis: Prospective Study
Introduction: Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. In 2013, an estimated 9.0 million people developed TB and 1.5 million died from the disease. TB is slowly declining each year an...