A Study on Adverse Drug Reactions in Tuberculosis Patients Maintained on DOTS Protocol in Government Chest &TB Hospital Warangal District
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Tuberculosis (TB) was one of the top most causes of death worldwide in 2015 and was responsible for more deaths than Malaria and HIV. So, aggressive treatment of TB is the need of the hour. On the flip side, the TB drugs are known to cause several adverse drug reactions (ADRs).This study aims to document various ADRs in TB patients maintained on DOTS protocol with first line drugs. Methods: A prospective observational study was carried out on 170 patients. The data was collected using a data collection form and the standard IPC-PvPI form prescribed by the WHO. The patients were also followed up on phone. Causality assessment was done by both WHO-UMC causality assessment scale, Naranjo algorithm and severity is assessed by Modified Hart Wig and Siegel scale. Results: Total number of ADRs detected was 260.Gastrointestinal ADRs outnumbered other ADRs (38.07%), by a wide margin it was followed up by Central nervous system (28.84%),Dermatological(8.84%),Psychological(05%),ototoxicity(3.07%),visionimpairment(1.92%),Arthralgia (1.92%),Edema(8.07%) &others(3.46%).Further, patients kept on CAT II drugs were found to be more prone to ADRs (48.8%) than CAT I drugs (21.1%). Conclusion: It’s alarming that several adverse drug reactions were found to drugs prescribed to fight a major public health challenge being faced by the world in general and India in particular i.e., TB. Sufficient data on these ADRs will go a long way in helping the medical professionals to prescribe the drugs with least side effects and minimize the suffering of the patients
Authors and Affiliations
Dr. D. Dhanalakshmi, V. Mouna Reddy, K. Anush, K. Anil Kumar, Farhanaz .
Keywords
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- EP ID EP238259
- DOI 10.9790/0853-1611040105
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