A STUDY ON ANTHELMINTIC AND ANTIBACTERIAL EFFECTS OF EXTRACTS FROM CHINESE HONEYSUCKLE (QUISQUALIS INDICA L) SEEDS AND ARECA (ARECA CATECHU) NUTS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objectives: This study aimed to investigate the anthelmintic and antibacterial effects of Chinese honeysuckle (Quisqualis indica L) seeds and Areca (Areca catechu) nuts, to verify their potentials of applying in practice. Materials and Methods: Aqueous extracts of plants at different concentrations were used to test with porcine ascarids, porcine flukes, and Escherichia coli (E. coli) strains isolated from pigs. The time that caused the death of 50% and 100% experimental endoparasites (LD50 and LD100) was used to verify the anthelmintic effects. Diameters of the inhibitory zone induced by extracts investigated with cylinder agar diffusion method were measured to assess their antibacterial effects. Results and Discussion: Both of Chinese honeysuckle seeds and areca nuts showed anthelmintic and antibacterial effects when tested against ascarides, flukes, and E. coli strains. These effects were all exerted in dose-dependent manners. Chinese honeysuckle seed extracts had stronger effects on ascarides, as shown by their significantly shorter LD50 and LD100 time. On the other hand, areca nut extracts were more effective against flukes and bacteria, which was evident by the significantly shorter lethal time values and significantly wider inhibitory zone diameters. Conclusion: This study demonstrated the anthelmintic and antibacterial effects of Chinese honeysuckle seeds and areca nuts, and therefore partly gives pharmacological basis to explain their traditional use in Vietnamese folk medicine. While Chinese honeysuckle seeds had more potential on ascarids, areca nuts were superior in effects against flukes and bacteria. However, future research that involved in vivo experiments is still required to further assess the applicability of these two promissory plants.
Authors and Affiliations
NGUYENTHANH HAI , MIYAMOTO ATSUSHI , HA THI THANH NGUYEN , THANH VAN NGUYEN
Keywords
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