A study on association of fibrinogen and oxidative stress in prognosis of diabetic foot ulcer in tertiary government hospital
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 9
Abstract
Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and long term complications. Diabetic foot ulcer has poor prognosis and is a leading cause of amputation. Oxidative stress is associated with the pathogenesis of chronic wounds. Fibrinogen is a prognostic marker of peripheral vascular disease. This prospective case-control study was designed to (i) evaluate and compare oxidative stress, protein carbonyl and fibrinogen levels, (ii) assess the correlation of the above parameters with prognosis in diabetic foot ulcer patients and healthy controls and (iii) whether fibrinogen levels can be used as prognostic markers.The study included 60 diabetic patients (30 diabetic foot ulcer grade 1 and 30 grade 2 patients). Oxidative stress was evaluated by estimating the amount of oxidant load of lipid peroxides by ferrous oxidation products in xylenol orange assay in conjunction with triphenylphosphine version 2 (FOX2 assay) and protein carbonyl. The antioxidant status level was estimated by ferric reducing ability of serum (FRAP assay). Fibrinogen and glycated hemoglobin was measured using commercial kits. SPSS version 17 was used for statistical analysis. Oxidative stress was higher in diabetic foot ulcer grade 2 patients compared to DFU grade1. Increased oxidative stress and plasma fibrinogen correlated with poor prognosis. Increased oxidative stress and plasma fibrinogen are associated with poor prognosis irrespective of glycemic control.
Authors and Affiliations
Dr. Naga Raju Vubbana
Keywords
Related Articles
- EP ID EP202629
- DOI -
- Views 91
- Downloads 0
Management of chronic non-healing wound by Hirudotherapy
A chronic wound is that wound which does not heal in an regular set of stages and in a expected amount of time or wounds that do not heal within three months are often considered chronic.[1] Chronic wounds often remain i...
Chemical and Bio-guided Evaluation of Some Natural Resins as Potential Antitumor Agents
Naturally occurring resins have beneficial pharmaceutical and nutraceutical properties. Based on the Ethnopharmacological literature, several species of natural resins used in traditional medicine were collected. In this...
A Review on Treatment for Neurodegenerative disease with the help of Nanosciences
Neurodegenerative disorders are those type of diseases which are responsible for malfunctioning of brain and peripheral nervous system. The therapeutic drugs which are being commonly utilized for the treatment for these...
A review on solid dispersion and latest approaches used to improve solubility of poorly water soluble drugs
In the present day solubility of drugs in GIT fluids becomes necessary for the preparation of solid unit dosage forms of drugs. Otherwise if the drug has poor solubility then the drug does not show its effect properly in...
Effect of methanolic extract of Piper cubeba Linn. fruits on the pharmacokinetics of Pioglitazone in rats
Herb-drug interaction about Oral antidiabetic drugs is a challenging concept. Present work was designed with an objective to investigate any possible pharmacokinetic effect of herbal drug Piper cubeba Linn. on Pioglitazo...