A Study on Association of Mean Platelet Volume and Ischemic Stroke
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Cerebrovascular diseases include some of the most common and devastating disorders. On the other hand, Mean platelet volume (MPV) is a physiological variable of haemostatic importance. Ischemic stroke is thought to occur as a result of thrombotic occlusion of a stenosed atherosclerotic blood vessel. Platelets are anucleate cells and are heterogeneous regarding their size, density &hemostatic potential. They play a crucial role in pathogenesis of atherosclerotic complications, contributing to thrombus formation. A morphological consideration of platelets has important implications for both interpreting the functional expression of platelets & experimental measurement of platelet size. Though there have been quite a few studies which have demonstrated an association between myocardial infarction and platelet size, very few studies have looked at the association between platelet size and ischemic stroke. This study was a prospective study carried out among fifty patients diagnosed with an acute ischemic stroke and presenting to the hospital within forty eight hours of onset of symptoms meeting our inclusion & exclusion criteria. Duration of study was between April 2016 to October 2017 at Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi. The study has shown an elevation of MPV in acute phase of ischemic stroke. Within this relationship and adjusting for other significant variables in multivariate regression analysis, it can be stated that an increase in MPV is independently associated with stroke, suggesting a role for larger platelets in the genesis of cerebral thrombosis.
Authors and Affiliations
Dr. Vaibhav Mathur, Dr. (Prof. ) Jeewan Kumar Mitra, Dr. (Prof. ) Bindey Kumar
Keywords
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- EP ID EP370312
- DOI 10.9790/0853-1704013546.
- Views 55
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