A Study on Biochemical Abnormalities in Neonatal Seizures
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Background: Neonatal seizure does not constitute a diagnosis but is a manifestation of an underlying disease of the central nervous system which may be due to systemic and biochemical disturbances. A study was conducted on neonates with seizures for a period of 1 year from 1st August 2016 to 31st July, 2017 Objective: To determine the biochemical abnormalities in neonatal seizures Design: Prospective cross-sectional hospital based study Setting: NICU of Gauhati Medical College and Hospital Methods: A prospective cross-sectional hospital based study was conducted on neonates with seizures admitted in NICU of Gauhati Medical College and Hospital for a period of 1 year from 1st August 2016 to 31st July, 2017. Term and preterm neonates with seizures admitted in NICU were included in the study. All necessary investigations performed were recorded Results:85 neonates (63.4%) out of 134 convulsing neonates had a biochemical abnormality either alone or in association with other etiologies. 49 neonates (36.5%) did not have any biochemical abnormality coincident on their etiology. 38 neonates (28.35%) had primary metabolic seizures of which hypoglycemia was the commonest biochemical abnormality and was present in 50% neonates in this group. Hypocalcemia was the next common abnormality and was present in 31.5% neonates within this group. 47 (55.2%) neonates had metabolic abnormalities superimposed or coincident on a primary illness like hypoxic ischemic encephalopathy, ICH, meningitis, sepsis etc. Metabolic abnormalities were more commonly associated with birth asphyxia and meningitis. Conclusion: Hypoglycemia (45.8%) followed by hypocalcemia (25.8%) and hyponatremia (18.8%) are the commonest overall biochemical abnormalities present in neonatal seizures. A thorough biochemical work up is necessary in all cases of neonatal seizure for early recognition and prompt management of biochemical abnormalities in neonatal seizure.
Authors and Affiliations
Gayatri Bezboruah, Nabanita Das
Keywords
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- EP ID EP573495
- DOI 10.9790/0853-1804105357.
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