A STUDY ON CASES OF PANCYTOPENIA WITH EVALUATION OF VARIOUS CLINICAL SYMPTOMS AND AETIOLOGIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 30
Abstract
BACKGROUND Several diseases can cause bone marrow failure, resulting in greatly reduced to absent haematopoiesis with subsequent pancytopenia. Pancytopenia which includes deficiency of all three cellular elements of blood resulting in anaemia, leucopoenia and thrombocytopenia is a common haematological entity that we have come across in routine practice. Hence a detailed clinical examination, thorough haematological investigation and bone marrow study of patients usually helps in identification of the underlying cause and adds to the pathologist’s role as a consultant to the patient’s treating physician. MATERIALS AND METHODS The study included 100 consecutive cases (both adult and children) with peripheral pancytopenia in the department of haematology (pathology) at SCB MC, Cuttack from January 2017 to April 2018. Patients receiving chemotherapy/radiation were excluded. Apart from detailed clinical examination, complete blood count, peripheral smear examination and bone marrow study (aspiration/trephine biopsy) were conducted. This was a cross sectional study. RESULTS The 100 consecutive cases showed a male predominance (58%). Most common clinical presentation was generalised weakness followed by fever. Most common cause for pancytopenia in adults was aplastic anaemia (40%) and acute leukaemia in children (60%). This was closely followed by Megaloblastic Anaemia (36%) whereas aplastic anaemia (40%) was second most common cause for pancytopenia among paediatric age group. Other causes included MDS with excess blast and hypersplenism. CONCLUSION Out of 100 consecutive cases, aplastic anaemia was most common cause of pancytopenia closely followed by megaloblastic anaemia in adults; whereas in paediatric cases, acute leukaemia was the most common cause followed by aplastic anaemia. The role of bone marrow study along with detailed clinical and haematological evaluation plays a very important role.
Authors and Affiliations
Priyadarshini Biswal, Dilleswari Pradhan, Asaranti Kar, Akhyaya Kumar Dash, Dharitri Mohanty
Keywords
Related Articles
- EP ID EP570012
- DOI 10.18410/jebmh/2018/458
- Views 97
- Downloads 0
A STUDY ON ASSOCIATION OF MICROALBUMINURIA IN NON-DIABETIC AND NONHYPERTENSIVE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
BACKGROUND Microalbuminuria is an emerging risk factor in evaluation of inhospital coronary events and long-term morbidity and mortality in patients with acute myocardial infarction. The primary aim of this study is to d...
IS MINIMAL INCISION THYROID SURGERY A BETTER ALTERNATIVE TO CONVENTIONAL AND ENDOSCOPIC THYROID SURGERY FOR SOLITARY THYROID NODULE?
The conventional technique of thyroidectomy for solitary thyroid nodule requires long skin incision, not satisfying patient and surgeon in terms of cosmesis and endoscopic thyroid surgery requires expertise. In our study...
OSTEOCHONDROMA ARISING FROM SPINOUS PROCESS OF L2, L3, L4 VERTEBRAE WITHOUT SPINAL CORD COMPRESSION: A RARE PRESENTATION
We here with present a case of osteochondroma arising from the spinous process of L2, L3, L4 vertebrae (Rt. Side) in a 28 years old male, labourer by profession presented to our hospital OPD on 08/11/2012 with chief comp...
VARIATIONS IN DIVISION OF SCIATIC NERVE: A CADAVERIC STUDY
INTRODUCTION Sciatic nerve is the largest and thickest nerve in the body. It arises from the lumbar plexus within the pelvis. The nerve emerges from the pelvis to enter into its component nerves –tibial and common perone...
RADIOLOGICAL EVALUATION OF CRANIOVERTEBRAL JUNCTION ANOMALIES
Detailed discussions of the CVJ are conspicuously absent in many standard textbooks and chapters addressing the skull or cervical spine, since it lies in between these regions. CVJ anomalies are common in India subcontin...