A study on comparison of gender-based prevalence and severity at presentation in spondyloarthritis in a tertiary care rheumatic center
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 12
Abstract
Introduction: Spondyloarthritis (or spondyloarthropathy) is the overall name for a family of inflammatory rheumatic diseases that can affect the spine and joints, ligaments and tendons. These diseases can cause fatigue and pain or stiffness in the back, neck, hands, knees, and ankles as well as inflammation of the eyes, skin, lungs, and heart valves. While there is no course of prevention at this time treatment can reduce discomfort and delay the development of spinal deformities. Aim of the study: The aim of the study was to differentiate gender difference at presentation of spondyloarthritis and to identify markers in determining the severity of disease. Materials and methods: This was a prospective observational study conducted for a period of 6 months at Institute of Rheumatology, Government K.A.P.V. Medical College and MGM Government Hospital. Totally 62 patients were included in the study 31 males and 31 consecutive females with features of spondyloarthritis per ASAS (Assessment of Spondyloarthritis international Society) at first presentation to our clinic were enrolled and their clinical characteristics were analyzed. Results: On comparing disease activity and functional indices between males and females, mean BASDAI was 4.66±1.8 versus 4.98±1.94 (p=0.5), mean BASFI was 4.6±2.3 versus 4.8±2.3 (p=0.7), mean BASMI was3.91±1.94 versus 4.18±2.06 (p=0.4). Out of 31 males, 17 were positive for HLA B27 and 6 out of 31 females were positive for HLA B27 (p=0.04). Conclusion: The pathogenesis of SpA is multifactorial and not yet fully understood. Genetic factors (HLA-B27 and non– HLA-B27 related genes), inflammatory cytokines (e.g. TNF-alpha, IL-1, IL-6, IL-7, IL-17, and IL-23) and environmental triggers (infections, mechanical stress, abnormal intestinal microbiota) play an important role. These different factors and their complex interaction can lead to activation of autoinflammation and autoimmunity and to the new bone formation. Men are more prone to spondyloarthritis when compared with women.
Authors and Affiliations
T. N Tamil Selvam, V. A. Sowndhariya, N. K. Senthil Nathan
Keywords
Related Articles
- EP ID EP425348
- DOI -
- Views 201
- Downloads 0
Autosomal dominant osteopetrosis type II
Osteopetrosis ("marble bone disease") is a descriptive term that refers to a group of rare, heritable disorders of the skeleton characterized by increased bone density on radiographs. The overall incidence of these condi...
Clinico-pathological study of lung malignancies in Mahabubnagar District, Telengana
Background and objectives: The objective of the present study was to study the the clinico-pathological profile of the lung cancer in Mahabubnagar....
Lipid profile in assessing the severity of cirrhosis
Background: Cirrhosis is a common hepatological disorder seen in clinical practice. Liver plays an essential role in lipid metabolism, several stages of lipid synthesis and transportation. It is reasonable to expect an a...
Dental caries and calculus status in children studying in Government and Private Schools in Malappuram, Kerala, India
Background: Dental caries status in children is influenced by a number of risk factors such as sex, age, socioeconomic status, diet, and oral hygiene practices. The objective of the study was to assess and compare the pr...
Bacteriological profile of surgical site infections
Background: Surgery has made great advances in last 3 quarters of this century and post-operative wound infection is the most common complication faced by surgeon since the advent of surgery. Aim: To determine the bacter...