A STUDY ON DETECTION OF GLYCOPEPTIDE RESISTANCE AMONG CLINICAL ISOLATES OF COAGULASE NEGATIVE STAPHYLOCOCCUS (CoNS) SPECIES IN A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 7
Abstract
BACKGROUND CoNS have become recognised as important agents of hospital acquired infections. Infections with CoNS occur mainly in patients with indwelling foreign devices, neonates and in immunocompromised patients. Some recent studies have pointed out reduced susceptibility of CoNS to Glycopeptide antibiotics. In view of the above perspective, the present study was carried out in a tertiary care hospital in Madurai to assess the prevalence of Glycopeptide resistant CoNS species in our region and also to assess the antibiotic of choice for them. MATERIALS AND METHODS The present study was a cross-sectional study conducted in Institute of Microbiology, Madurai Medical College, Madurai. The study period was from November 2014 to August 2015. A total of 104 CoNS species were isolated from clinical samples, collected from the patients admitted in various wards of Government Rajaji Hospital, Madurai and processed using conventional microbiological methods. RESULTS Among the 104 CoNS species 72 were S. epidermidis, 19 were S. lugdunensis, 11 were S. haemolyticus and 2 were S. saprophyticus. Among them, 28 (26.92%) were Methicillin Resistant CoNS (MRCoNS) and 76 (73.08%) were Methicillin Sensitive CoNS (MSCoNS). Phenotypic detection of Glycopeptide resistance among Methicillin Resistant Staphylococci by various methods showed one isolate 3.6% (among MRCoNS) to be Vancomycin Intermediate S. epidermidis (VISE) from blood sample. This isolate was susceptible to Gentamicin, Teicoplanin, Linezolid, Rifampicin, Quinupristin/ Dalfopristin by reference CLSI methods. CONCLUSION Early detection of these strains is crucial to establish an appropriate antimicrobial therapy, thereby reducing the mortality and morbidity associated with these infections and also to prevent hospital acquired infections.
Authors and Affiliations
Meerah S, Jagatheeswary P. A. T.
Keywords
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- EP ID EP399044
- DOI 10.14260/jemds/2018/189
- Views 81
- Downloads 0
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