A Study on Diagnostic Importance of Serum Cholinesterase Activity in Hepatic Diseases and Non- Hepatic Diseases
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
A variety of laboratory tests are used in the evaluation of hepatic patients. Serum cholinesterase is reduced in liver dysfunction in contrast to other enzymes. Liver is the main source of Pseudocholinesterase. A comparative study of Pseudocholinesterase along with other relevant liver function test parameters were investigated in different hepatic disorders in present study. The present study was designed to compared the levels of the serum cholinestearse with convectional liver functions tests to determine whether the single estimation of serum CHE level can help to distiniguish hepatic disease from non- hepatic diseases. Total 100 subjects of both sex with age ranged from 15 to 65 years were selected for the study. All the subjects were then divided into two groups, 50 hepatic diseases subjects and 50 non-hepatic diseases subjects. Then liver function tests were evaluated by estimating comprising total billirubin, direct billirubin, indirect billirubin total plasma protein, albumin, globulin serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, serum alkaline phosphatases and Serum cholinesterase of both the groups. In this study all the parameters show highly significant changes in hepatic diseased as compared to non - hepatic diseased group. (p< 0.001). Serum cholinesterase values were significantly lowers in hepatic disease patients and mean ± SD value was 10.81±2.74KU/L as compared to non hepatic diseased patients (23.56±2.41). Data present study clearly states that serum cholinesterase activity alone can be useful to differentiate liver diseases from non- liver diseases. It is cost effective as compared to conventional liver function tests whenever there is need to excluded liver involvement. Keywords: Serum Pseudocholinesterase, Hepatic diseases, Non- hepatic disease.
Authors and Affiliations
Vihan Chowdhary, Ranjana Mathur, Raghuveer Choudhary, Kamla Choudhary, Sonika Choudhary
Keywords
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