A Study on Effect of Ageing on the Levels of Total Antioxidant and Lipid Peroxidation
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Aging has raised significant social and health concern worldwide. Aging can be viewed as a process of irreversible cell injuries associated with the accumulation of oxygen derived free-radicals. The present study was undertaken to evaluate the changes that occur due to ageing on the levels of Total antioxidant concentration and lipid peroxidation. Material and methods: Fifty healthy non-smoking elderly individuals without major illness belongs to the age group of >60years and fifty non-smoking young adults of age group of 18-40 years and who were willing to take part in the study were included after their consent institutional ethical clearance. A 5ml of venous blood was collected, serum was separated and used for the analysis of total antioxidant capacity and Malondialdehyde level. Result: The results of the present study showed a significant decrease (p<0.05) in TAC elderly individuals as compared to the young adults and a significant increase (p<0.0001) in the MDA levels in the elderly population in comparison with the young adult population. Conclusion: It can be concluded from the study, that a significant decrease in the antioxidant level and increase in the level of oxidative stress was observed as the age increases. This direct towards considering the levels of these oxidative stress markers as an important marker for the ageing
Authors and Affiliations
Nandana Muralidharan, Tanmay Bhat, Suchetha Kumari N
Keywords
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