A study on hepatoprotective activity of aqueous seed extract of Vigna Unguiculata (l) Walp against ethanol induced hepatotoxicity in rats
Journal Title: Journal of Pharmaceutical and Biological Sciences - Year 2017, Vol 5, Issue 3
Abstract
In the present study, the aqueous extract of Vigna unguiculata (L) Walp seed was evaluated for its hepatoprotective effect on etahnol induced acute liver damage on Wistar albino rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin (TB), superoxide dismutase (SOD), lipid peroxidation (LPO), glutathione (GSH), and catalase (CAT) levels. Ethanol induced group had enhanced levels of SGPT, SGOT, ALP, TB & LPO and decreased levels of GSH, SOD and CAT when compared with control group. Treatment with silymarin, 200mg/kg and 400mg/kg of Vigna unguiculata (L) Walp seed extract had significantly brought down the elevated levels of SGPT, SGOT, ALP, TB & LPO and an increase in the levels of GSH, SOD, LPO and CAT. The results showed that aqueous extract of Vigna unguiculata (L) Walp seeds possesses significant hepatoprotective activity.
Authors and Affiliations
Ibrahim Sayeed V K, Satish S, Ajay Kumar K, Chaitra Amin B
Keywords
Related Articles
- EP ID EP321750
- DOI -
- Views 109
- Downloads 0
Chronic agmatine treatment modulates behavioral deficits induced by chronic unpredictable stress in wistar rats
Aim Stressful life events modifies brain neuronal structure that impairs normal brain functions and leads to behavioral deficiencies Agmatine is a wellrecognized neurotransmitter and has been reported to be released as a...
Impact of anxiety on stuttering: Neurobehavioral aspects
Purpose To investigate the impact of anxiety related stuttering and severity of stuttering related to neurobehavioral changes including demographics of the people who stutter Materials and Method A casecontrol observatio...
Impact of rifaximin potency after treatment with different solvents
Rifaximin is an oral antibiotic used for the treatment of hepatic encephalopathy, ulcerative colitis, irritable bowel syndrome, Clostridium difficile, travelers' diarrhea and acute diarrhea. Production of rifaximin invol...
Perioperative antimicrobial prophylaxis in surgery and adherence to guidelines
Introduction Surgical Antimicrobial Prophylaxis SAP lowers postoperative surgical site infection SSI if used with American Society of HealthSystem Pharmacists ASHP guidelinesObjective The present study was carried out wi...
Separation and Characterization of Deamidated Isoforms in Insulin Analogue and its Underlying Mechanism
Deamidation of proteins has remained an elusive phenomenon largely down to the gap that exists in its understanding. One of the primary reasons, is that the experimentation involved is time consuming. However, it remains...