A study on histopathological changes in placenta in pre-eclampsia/eclampsia: A case-control study in tertiary care centre, western India
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction In pregnancy induced hypertension PIH pathological changes in the placenta occurs which may result in reduced blood flow across placenta The present study has been undertaken to assess the morphology histology of placenta from mothers with PIH and to correlate their findings with those of normal pregnanciesMaterials and Methods The present study was a casecontrol study conducted during July 2015 to September 2017 Placenta of cases of singleton normal pregnancies those complicated by preeclampsia eclampsia and of known gestational period were included The placentae were divided into two groups Group 1 Pregnancy with hypertension cases and Group 2 Normal pregnancy control Detailed macroscopic and microscopic examinations were conducted on the placentaeResults The mean weight of placenta 474 58 grams was higher among control group in comparison to PIH group 420 61 grams This difference was statistically significant p 0001 The mean fetoplacental weight ratio 614 0503 was higher among PIH group in comparison to control group 603 0409 This difference was statistically insignificant p 005 There was significant association between presence of gross infarction calcification Hyalinised area 10 lpf medial coat proliferation 10 lpf intervillous hemorrhage decreased villous vascularity and PIHConclusion It is concluded that there was statistically significant difference between mean birth weight of the babies and mean placental weight in control group and PIH group It also revealed striking villous lesions like increased syncytial knots cytotrophoblastic cell proliferation villous stromal fibrosis and fibrinoid necrosis in placenta from preeclampsia cases Keywords Placenta Histopathological Changes Preeclampsia Eclampsia
Authors and Affiliations
CR Gore, Aditi Pandey, Abhinav Shetty, Ruby Rao, Sourabh Paranjape
Keywords
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- EP ID EP475902
- DOI 10.18231/2394-6792.2018.0075
- Views 68
- Downloads 0
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