A Study on Management and Treatment Outcomes of Metastatic Breast Cancer: Ten Years Experience in Alexandria University Hospitals
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
Patients with metastatic breast cancer represent a heterogeneous group, whose prognosis and outcome may be dependent on multiple patient and tumor related factors. The objective of this retrospective study was to review demographic and clinico pathologic features and assesses treatment outcomes in primary metastatic breast cancer patients. During the period from January 2003 to December 2012, 302 patients with stage IV breast cancer at time of diagnosis treated at Clinical Oncology and Nuclear Medicine Department, Alexandria Main University Hospital were included in this analysis. Comprehensive clinico pathologic and treatment-related data were retrieved from medical records, survival outcomes were estimated and correlated to various prognostic and predictive factors. In results the median follow-up time was 16 months. The median progression free survival (PFS) after first line treatment was 10 months, while the median overall survival (OS) time was 18 months. Older age, positive hormonal receptor status and bone/soft tissue metastases only were associated with an improved survival. Whereas, menopausal status and loco regional treatment were not found to be statistically significant predictors of survival. In conclusion the general characteristics of the primary tumor are important for the prognosis and survival of patients with denovo metastatic breast cancer. These should be taken in account to achieve appropriate individualized therapeutic decisions. Keywords: primary metastatic breast cancer, prognostic factors, survival
Authors and Affiliations
Kandil A, Abdelaziz A, Khedr G, Fahmy I
Keywords
Related Articles
- EP ID EP373325
- DOI -
- Views 53
- Downloads 0
Head and Neck Cancer: Current Treatment Options and Associated Challenges
Head and neck squamous cell carcinoma (HNSCC) is one the most common malignancies in which significant advances in treatment modalities have yet to be translated into better clinical outcome except for cases associated w...
A Study of the Efficacy of Ultrasound Guided Tap Block Using 0.375% Ropivacaine for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
As important component of the pain experienced by patients after abdominal surgery derives from the abdominal wall incision so the TAP block, as part of a multimodal analgesic regimen, may result in improved analgesia an...
Why we are not using condoms regularly? A qualitative study among men who have sex with men in Northern India
Abstract:The high risk groups such as men who have sex with men (MSM), Female sex workers (FSW) and Injectable drug users (IDU) are the main drivers of the HIV epidemic in India. The condom has been recognized as an impo...
A Comparative Study of Ondansetron versus Ramosetron on Post Operative Nausea and Vomiting in Gynecological Surgeries
Postoperative nausea and vomiting (PONV) is one of the most unpleasant and distressing symptoms which follow anaesthesia and surgery and lead to serious postoperative complications. PONV commonly occurs within 24 hours a...
A Study on the Efficacy of Mesotherapy with Finasteride versus Oral Finasteride for the Treatment of Androgenetic Alopecia
Abstract: Androgenetic alopecia is condition of patterned hair loss. It is a psychologically distressing condition. Mesotherapy is a technique of delivery of topical solutions in the middle layer of the skin.The aim is...