“A Study on Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus and Its Correlation with Albuminuria And Its Prognostic Significance”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background : Diabetes mellitus is a syndrome of altered carbohydrate metabolism characterised by deficiency of endogenous insulin production or defect in insulin secretion or peripheral resistance to insulin action. Mean platelet volume is one of the haematological parameters used to assess platelet function and activity. Large volumes correlates with increased platelet activity, and this in turn is associated with increased vascular complications in diabetes mellitus. Smaller mean platelet volumes on theon the other hand are associated with reduced platelet activity. Objectives :To estimate the mean platelet volume in an uncomplicated type 2diabetes mellitus and to compare with normal controls . To determine the association between mean platelet volume across various levels of albuminuria, thereby relating its association with vascular complications of diabetes, specifically diabetic nephropathy. Methods :A Cross sectional study was done at Institute of internal medicine,Madras medical college and Rajiv Gandhi government general hospital, Chennai from September 2016 to May 2017 in confirmed cases of type 2 diabetes mellitus &Non diabetic controls without coronary artery disease.Atotal of 140 patients which includes 90 diabetics and 50 controls. Healthy subjects who attended routine master health check ups were taken as control group were subjected to detailed history, examinations and investigations as needed and statistical analysis were done using SPSS software 17.0 Results :A total number of 140 patients participated in our study that includes 90 (64 %) type 2 diabetes mellitus patients and 50 (36%) age matched healthy controls. Among them 88are females.In our diabetes group, 55 patients(61%) are males and 35 patients(39%) are females. The mean platelet volume was significantly higher (8.8± 0.36) in the diabetes patients when compared to control(7.93± 0.24) group and is statistically significant (p<0.0001) by independent sample t test.The mean MPV in A1 group is (8.45± 0.19) which was lower than A2(8.87± 0.37). both groups were lower than A3 (8.99±0.27). Statistical significance exists between A1and other groups (p <0.0001) , but A2 and A3 does not show any statistical significance by independent t test.
Authors and Affiliations
Dr. A. Raghupathi, Dr. R. Penchalaiah MD
Keywords
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- EP ID EP374573
- DOI 10.9790/0853-1705060104.
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