A Study on Prevalence of Elevated HSCRP in Acute Vascular Events
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Acute vascular events like coronary and cerebrovascular accidents continue to be a major public health problem in the industrialised and developing countries in diagnosis and management over last three decades. The role of inflammation pathogenesis of atherosclerosis has been firmly established in past two decades. Numerous studies have shown association of pro-inflammatory biomarkers with incident hypertension, metabolic syndrome, coronary artery disease, ACS, stroke, peripheral artery disease, recurrent coronary and cerebrovascular events. High sensitive CRP is a sensitive marker of inflammation and tissue injury in arterial wall. CRP is a glycoprotein, produced by liver and plays a vital role in development of atherosclerotic disease in cardiac and cerebral circulation, the serum level of which has long been known to increase the risk of acute vascular events. In clinical studies, circulating HsCRP has been bound to correlate with prognosis of acute vascular events. Thus, HsCRP is an indicator of underlying inflammation. Study aims and objectives were to determine the prevalence of elevated HsCRP in 50 patients with acute vascular events. To compare with 50 controls of non vascular acute event. To determine role of hsCRP in determining the morbidity and mortality. To analyze the levels of hsCRP in patient without any other specific CVS risk factors. Material and Methods: A 50 cases were enrolled for the study, who attended the inpatient clinics and who were admitted in the Department of Internal Medicine and Department of Cardiology, Government General Hospital, Guntur, Andhra Pradesh. Patients selected for the study, satisfied all the inclusion and exclusion criteria. Written consent was obtained from all patients participating in the study. Age and sex matched controls (50) were also studied for comparison and meaningful interpretation of data. The controls were recruited from other acute cases that were recruited from the wards. Results: The prevalence of elevated Hs CRP in selected cases >0.3mg/L - 46/50(92%).Prevalence of elevated Hs CRP in control >0.3mg/L - 35/50(70%). Most of the cases were between age 40 and 60year, we had found that mean age of cases is 51.4years.There is male predominance and, Sex wise distribution male 34(68%), female 16(32%). Conclusion: In our study it is clearly shown that most of patient selected had very high prevalence (92%) of elevated hsCRP among patients with acute vascular events. Level of elevated hsCRP more in vascular events than compared to non vascular events Elevated hsCRP is no role in mortality and morbidity vascular events A high prevalence (93.3) of elevated HsCRP patients with acute vascular events without risk factors.
Authors and Affiliations
N. Kalyani, K. Chandana
Keywords
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