A Study on Seroconversion in HBeAg Antigen Positive Chronic Hepatitis B Patients with Tenofovir Therapy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 9
Abstract
Introduction: Chronic Hepatitis B remains most important risk factor for developing cirrhosis, hepatic decompensation and hepatocellular carcinoma. So treatment with tenofovir of HbeAg positive Chronic Hepatitis B and seroconversion is the major concern. Aim: To see the HbeAg and HbsAg loss after receiving tenofovic therapy for 6 and 12 months. Methodology: A hospital based prospective study conducted on 50 chronic hepatitis B infection with HbeAg antigen positive patients between age group 12 to 60 years, receiving tenofovir (300mg) was taken for study. HbeAg, HbsAg and liver enzyme status was checked at the end of 6 months and 12 months. Results: ALT level became normal (<19mg/ml) in 37.5 % of female patients at the end of 12 months study and in male it was 67.65%. Overall biochemical response was 58%. All patients were HbeAg reactive at the end of 6 months of tenofovir therapy but 48 percent became non reactive at the end of 12 months. Overall seroconverson was 36 percent at the end of 12 months. Conclusion: There is statistical significant number of HbeAg loss, normalization of ALT level and HbeAg seroconversion at the end of 1 year. HBV DNA level became undetectable level in all sero converted groups.
Authors and Affiliations
Pinaki Nath
Keywords
Related Articles
- EP ID EP515061
- DOI -
- Views 114
- Downloads 0
Effect of Radiotherapy on Oxidative Stress and Serum Adenosine Deaminase Levels in Carcinoma Cervix Patients
Carcinoma cervix is the most prevalent genital tract cancers in the world including India. Low levels of antioxidants induce the generation of free radicals leading to DNA damage and further mutations. Alterations in enz...
Pattern of Co-morbidities in Children with Severe Acute Malnutrition admitted in MTC of a teaching hospital of Westeren Rajasthan, India
Objective: To study the pattern of co-morbidities in children having Severe Acute Malnutrition in MTC attached to a teaching hospital. Methods: In a span of five years all the children (1082), admitted in MTC of PBM Hosp...
Evaluation of Lesions of Lymph Node in a Rural Teaching Hospital in one year (2017)
Introduction: As a part of peripheral or secondary lymphoid organs, lymph nodes are a vital part of immune system. Their increase in size is referred to in a huge spectrum of diseases, inclusive of infections and maligna...
Heart Failure with Preserved Ejection Fraction: Is this Relevant?
Heart failure with preserved ejection fraction (HFpEF) is more common in people of old age. In Indian population, HFpEF has been unified with hypertension, diabetes mellitus and artherosclerosis in most of the cases. In...
Comparative Evaluation of CT Enterography and MR Enterography in Evaluation of Small Bowel Pathologies
Aims and objectives: 1) To study the role of CT Enterography and MR Enterography in diagnosing various small bowel diseases.2 )To compare the diagnostic significance of CT Enterography with MR Enterography 3)To evaluate...