A study on the outcome of pulse therapy in vesicobullous disorders at a tertiary care centre in Chidambaram, Tamilnadu
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 4
Abstract
Introduction With the advent of pulse therapy and adjuvant immunosuppressive drugs the outcome and prognosis of vesicobullous disorders have been improved to a greater extent Different regimen protocol has been tried and this descriptive study was carried out to assess the outcome of various pulse therapy regimens in vesicobullous disorder at our centreMethods A total of 26 vesicobullous patients were enrolled for the study Diagnosis was made clinically and confirmed by histopathology They received treatment with DexamethasoneCyclophosphamide pulse DCP or Dexamethasone Azathioprine pulse DAP or Dexamethasone pulse DP therapy and were followed up for clinical remission and side effects of therapyResults There was a total of 26 patients comprising 6923 females and 3077 males and 50 were between the age group of 4050 years Pemphigus vulgaris was the commonest clinical type seen in 6923DCP was given for 228462 patients dexamethasone pulse in 31154 and DAP in one 385 In DCP group 7727 of patients were in Phase I and 2273 achieved clinical remission One patient was refractory to DCP and required rituximab infusion Weakness headache vomiting and weight gain were the commonest side effects encountered in our study Avascular necrosis of femur and reactivation of pulmonary tuberculosis were the major side effects noticed in one patient eachConclusion DCP therapy prove to be an excellent therapeutic regimen in case of vesicobullous disorders to attain faster recovery sparing the adverse effect of corticosteroids DAP can be an useful therapeutic option in patients who were unmarried or in reproductive age groupKeywords Pemphigus vulgaris Dexamethasonecyclophosphamide pulse Dexamethasoneazathioprine pulse Dexamethasone pulse
Authors and Affiliations
Kannambal K. , Prasad P. V. S. , Kaviarasan P. K. , Poorana B. , Ranjani D.
Keywords
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- EP ID EP488917
- DOI 10.18231/2581-4729.2018.0061
- Views 94
- Downloads 0
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