A STUDY ON THE PHENOTYPIC FREQUENCIES OF Rh ANTIGENS AMONG BLOOD DONORS OF A TEACHING INSTITUTION, KERALA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 43
Abstract
BACKGROUND India is a vast country with several population groups. But minimum data is available about the frequency of different Rh blood group antigens among the Indian population, whereas no data has been reported from Kerala till date. The antigen frequency in a specific population may help us to assess the risk of antibody formation and which in turn may give direction to get an antigennegative compatible blood for patients who have multiple red cell alloantibodies. This study was carried out to determine the frequencies of Rh blood group antigens D, C, c, E and e among 500 blood donors. MATERIALS AND METHODS This is a descriptive study done on 500 blood donors who came to the Department of Transfusion Medicine, Govt. T. D. Medical College, Alappuzha. Samples from randomly selected blood donors of nearby areas (both voluntary and replacement) were collected for extended Rh antigen phenotyping during the one-year period of study (February 2015 to January 2016). RESULTS Among the 500 blood donors included in the study, 470 (94%) were males and 30 (6%) were females. 86.6% (n= 433) of the donors were found to be Rh D positive and the remaining 13.4% (n= 67) were Rh D negative. Most common Rh antigen observed in the study population was e (96.8%) followed by D (86.6%), C (80.8%), c (61%) and at last E (12.4%). Out of 433 Rh D positive randomly selected blood donors in the study, the most common phenotype was found to be R1R1 (39%) followed by R1r (34.6%). Among 67 Rh D negative subjects, r r was the commonest phenotype (60 out of 67). CONCLUSION This study emphasises the need for implementing Rh-phenotyping on routine blood grouping to provide antigen negative compatible blood when in demand. Rh antigenic phenotyping along with antibody identification is crucial, especially in transfusion dependent and multiparous females. It is a vital requirement of a quality transfusion service. From the different reaction patterns observed in this study, the prevalence of probable Rh phenotypes were assessed and it helped to create an antigen negative donor database.
Authors and Affiliations
Anjana Mohan, Sasikala Nadanganan, Meena Dharmadas
Keywords
Related Articles
- EP ID EP549024
- DOI 10.14260/jemds/2018/1043
- Views 92
- Downloads 0
PULMONARY TUBERCULOSIS IN CHRONIC KIDNEY DISEASE PATIENTS ON MAINTENANCE HAEMODIALYSIS- A TERTIARY CARE CENTRE’S EXPERIENCE
BACKGROUND Patients of chronic kidney disease on maintenance haemodialysis are many fold prone to manifest active tuberculosis when compared to the general population. Not only is the timely diagnosis, but also the thera...
FACTORS ASSOCIATED WITH EARLY INITIATION OF BREASTFEEDING AMONG MOTHERS OF DIBRUGARH DISTRICT, ASSAM- A COMMUNITY-BASED CROSS-SECTIONAL STUDY
BACKGROUND Early or timely initiation of breastfeeding, specifically within 1 hour of birth, refers to the best practice recommended by the World Health Organization (WHO). There is growing evidence of the significant im...
BACTERIOLOGICAL PROFILE OF VENTILATOR ASSOCIATED PNEUMONIA IN A TERTIARY CARE CENTRE OF DAKSHINA KANNADA DIST.
BACKGROUND Mechanical ventilation can increase the risk of VAP 7 - 21 times and 10% - 25% of patients undergoing mechanical ventilation develop pneumonia. The aetiological agents of VAP vary with different patient popula...
STUDY ON PREGNANCY OUTCOME IN PRETERM PREMATURE RUPTURE OF MEMBRANES WITH OLIGOHYDRAMNIOS
BACKGROUND Pregnancy outcome in preterm premature rupture of membranes is affected by AFI. PPROM with oligohydramnios (AFI<5) affects maternal outcome in terms of latency period, complications like chorioamnionitis, mode...
A STUDY ON MEDICAL FITNESS OF UNDERGRADUATE MEDICAL STUDENTS WITH REFERENCES FOR FURTHER IMPROVEMENT OF THEIR HEALTH
BACKGROUND The medical students undergoing MBBS course are busy all the time in their lessons and other academic activities. There is hardly any time of taking care of their health and they are reluctant to exercise. The...