A study on the role of receptor (ER,PR,HER-2/neu) in patients of carcinoma breast
Journal Title: International Journal Of Medical Science And Clinical Invention - Year 2017, Vol 4, Issue 10
Abstract
Objective: To evaluate the expression of HER-2/neu, estrogen receptor (ER) and progesterone receptor (PR) in breast carcinomas. Methods: This was a prospective hospital based study conducted on patients of carcinoma breast. The study population comprised of patients who were diagnosed to have carcinoma breast on the basis of preliminary Trucut biopsy/ open biopsies, and subsequently underwent surgery for the disease. All patients who had undergone previous chemo or radiotherapy were excluded from the study. A total of 72 patients were included in the study. Results: About one third of patients were between 41-50 years of age (30.6%). TNM stage IIIB was among in 30.6% patients and IIIA was in 25%. Tumor grade III was among more than half of patients (61.1%). Infiltrating ductal carcinoma was among 88.9% patients. ER and PR was positive in 41.7% and 25% patients respectively. ER-/PR- was among 54.2% patients. HER2neu was positive in 22.2% of the patients. Luminal A and B was in 36.1% and 13.9% patients respectively. Conclusion: Breast cancer in Indian patients has been found to be histologically aggressive, presents at a younger age, and is less likely to be susceptible to conventional hormonal and targeted antibody treatment. Detecting and treating this increasingly important cause of mortality is an enormous challenge.
Authors and Affiliations
Dr Imtiyz Ahmed , Dr Nida Fatima , Prof. Tariq Mansoor , Dr Pankaj Singh
Keywords
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- EP ID EP315571
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