A STUDY ON TOPICAL USE OF PHENYTOIN SODIUM IN GRADE I AND GRADE II DIABETIC FOOT ULCERS
Journal Title: International Journal Of Advances In Surgery - Year 2017, Vol 1, Issue 5
Abstract
Introduction: Diabetic foot ulcer is the most common complication of diabetes mellitus. Most of the patients with diabetes seek hospital admission due to a diabetic foot ulcer. About 15% of diabetic patients have ended up with surgery following diabetic ulcer complications. Objective: The objective of this study was carried out to assess the efficacy of topical application of phenytoin sodium powder on healing in diabetic foot ulcer grade I and II. Materials and Methods: The entire sample population 100 was divided into two equal groups that can be comparable, which is further divided into 3 subgroups : moderate and poor control based on HBA1C value assigned regular saline dressing for the control group and phenytoin sodium powder application for study group. Patients fulfilled the inclusion and exclusion criteria. Both the control and study group are compared for the reduction in the surface area, granulating tissue formation, duration of hospital stay, wound swab for culture and sensitivity. effect of granulation tissue formation based on HBA1C value and graft uptake to assess the healing process. Results: The wound healing was assessed by the formation of granulation tissue, decrease in surface area, wound swab for culture and sensitivity, duration of hospital stay and graft uptake post surgery. At the end of 14 days, the presence of healthy granulation tissue were markedly noted in 90% of study group with phenytoin, and it was present only in 10% of control group. Moreover, also wound reduction was 66% in the study group, and 44% in the control group. Graft uptake in study group post surgery was 95.3% superior compared to the control group which was 66.6%. Mean duration of time in the hospital is also significantly reduced in phenytoin group which was 21 days compared to control group which was 40days. Conclusion: On this study and literature review, we conclude phenytoin sodium powder topical application on diabetic foot ulcer promotes early wound healing.
Authors and Affiliations
Dr. K. Arul Kumaran, Dr. P. Harishwaran, Dr. B. Aravind
Keywords
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