A STUDY TO ASSES THE EFFECT OF DEXMEDETOMIDINE VERSUS MIDAZOLAM FOR SEDATION OF CRITICALLY ILL PATIENTS.
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 8
Abstract
Background: Sedation is a common practice in ICU in order to reduce the anxiety, increase tolerance and to improve the outcomes of intervention is the Intensive care Unit. This is due to patients admitted to the ICU require invasive and uncomfortable interventions such as mechanical ventilation. The sedation of the patient reduces the stress response, provides anxiolysis, improves the tolerance of ventilator support and facilitates nursing care. Objective: To compare the effect of Dexmedetomidine versus Midazolam for sedation of critically ill patients. Materials and Methods: A prospective, randomized, double blinded study was undertaken in the Department of Emergency Medicine, of Chigateri General Hospital and Bapuji Hospitals attached to JJM Medical College, Davanagere from March 2012 to March 2013. A total of 100 patients aged above 18 years who were critically ill and admitted to Intensive care units of the above hospitals were included as subjects. Results: The mean age of the subjects of Dexmedetomidine group was 41.9 (±12.4) years and patients of midazolam group was 41.1 years.The mean weight of the patients in Dexmedetomidine group was 57.2 (±13.5) kgs and the mean weight of the patients in Midazolam group was 57.8 (±12.2) Kgs.The mean sedation score was 0.6 in dexmedetomidine group and 0.1 in Midazolam group at 5 mins after admission. Conclusion: This study had shown the efficacy of Dexmedetomidine as equal as Midazolam. The hemodynamic parameters also remained normal while use of this drug. This study had also shown that the less adverse effects and number of add on sedative agents were less in Dexmedetomidine group compared to midazolam.
Authors and Affiliations
Imran Sholapur
Keywords
Related Articles
- EP ID EP536355
- DOI 10.21088/ijaa.2349.8471.5818.12
- Views 60
- Downloads 0
A Comparative Study between Bupivacaine and Clonidine Combination versus Bupivacaine (Plain) for Brachial Plexus blocks using Supraclavicular Approach
Background: Brachial plexus block achieves ideal operating conditions by producing complete muscle relaxation, maintaining stable intra-operative hemodynamics and associated sympathetic block. Usage of adjuvant drugs alo...
A Comparative Study of Efficacy of Bupivacaine and Ropivacaine with Fentanyl in Epidural Labour Analgesia
Introduction: Labour is a highly complex and personal process for every woman. Analgesic intervention is a matter of personal choice for delivery. Local anesthesia given as an epidural injection along with an opioid give...
Prospective Study to Evaluate the Role of Vasopressin in Hypernatremia Treatment in Brain Dead Patients
Brain dead patients are potential organ donors but the pathological changes associated with braindeath can affect graft survival. Among various effects of braindeath endocrine and autonomic changes are noteworthy. Centra...
Aero - Digestive Foreign Bodies in Tertiary Care Hospital of Southern Rajasthan: One Year Prospective Study
Backgound and Aim: Foreign body lodgement in aero-digestive tract is a common surgical emergency presenting to the department which contributes to high morbidity and occasional mortality. Severity of symptoms depends upo...
Addition of Morphine to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block Prolongs Postoperative Analgesia after Gynaecological Cancer Surgery
Background: There is significant postoperative pain in major gynecological cancer surgery patients. Ultrasound (USG) guided Transversus Abdominis Plane (TAP) block is a novel approach to provide analgesia to anterior abd...