A Study to Assess the Therapeutic Effect of Enalapril on Olanzapine Induced Metabolic Syndrome in Wistar Rats
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 2
Abstract
Introduction: Metabolic Syndrome (MS) is a complex of risk factors for the development of cardiovascular complications and Type 2 Diabetes Mellitus (DM). Pharmacological management of the condition is complex, as multiple drug groups have to be used, as the syndrome itself is multi faceted. Angiotensin Converting Enzyme Inhibitors (ACEIs) are chiefly used to manage the hypertensive component of the syndrome. However, recent studies have shown that these drugs may have a role in the non hypertensive aspects of the syndrome as well. Aim: To evaluate the therapeutic effect of enalapril on total body weight, random blood glucose and serum lipid profile in a rodent model of olanzapine induced MS. Materials and Methods: Three different dosages (1 mg/kg/ day, 10 mg/kg/day and 20 mg/kg/day) of oral enalapril were administered (for three weeks) in albino wistar rats, which received prior intra peritoneal olanzapine (for three weeks), and compared against control (normal saline) and standard (olanzapine only and enalapril only) groups. Parameters like total body weight, random blood glucose and serum lipid profile were measured at baseline, at three weeks and at six weeks. Results: Enalapril at 20 mg/kg/day was found to be effective in reversing the weight gain, hyperglycaemia and hypercholesterolaemia, without any changes in triglycerides, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL). 10 mg/kg/day of enalapril prevented any further rise in body weight, blood glucose, total cholesterol and serum triglycerides, after olanzapine was stopped. 1 mg/kg/day of enalapril was ineffective. Conclusion: High dose of enalapril may be considered as a component of therapeutic regimens to combat weight gain, hyperglycaemia and dyslipidaemia seen in MS, in addition to its antihypertensive utility. Further rodent and clinical studies may be required to ascertain the same.
Authors and Affiliations
Avinash Arivazhahan, Laxminarayana Kurady Bairy, Veena Naya, Sushil Kiran Kunder
Keywords
Related Articles
- EP ID EP332254
- DOI 10.7860/JCDR/2017/24049.9380
- Views 101
- Downloads 0
Misdiagnosis: How Uncommonly Common is it?
ABSTRACT Introduction: General dentists may be the first dental practitioners to see children with dental problems. ‘Misdiagnosis’ of certain commonly occurring dental conditions in children by general dentists may lead...
Morphometric Evaluation of Adult Acromion Process in North Indian Population
Introduction: Dimensions of acromion process are important to show linkage to the shoulder girdle pathologies. Also morphometric analysis of acromion process would be helpful for surgeons while performing surgical proced...
Variant Insertion of Deltoid Muscle
During the routine dissection for the undergraduate medical students a unilateral variation was seen in the insertion of deltoid muscle in the left arm. The muscle took origin as usual. The most anterior clavicular fiber...
Characterisation of Breast Cancer Lesions using Image Processing Based Technique
ABSTRACT Introduction: Characterisation of mammographs deliberates as influential approaches in cataloguing of breast tissues and tumour. In breast, unravelling of nearby tissues in the mammographs is one of the tough pr...
Estimation of Serum Butyryl Cholinesterase in Patients with Oral Squamous Cell Carcinoma: A Cross-Sectional Study
Introduction: Oral cancer is a major global threat to public health. It is one of the most common causes of mortality and morbidity in the modern era. Oral Squamous Cell Carcinoma (OSCC) accounts for over 90% of the mali...