A study to compare prognostic utility of procalcitonin with existing biomarkers (CRP and TLC) and clinical risk scores (PSI and CURB 65) in community acquired pneumonia
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 1
Abstract
Background: Community - acquired pneumonia (CAP) is a leading cause of morbidity and mortality. Biomarkers are increasingly being used to distinguish bacterial pneumonia from other causes, to help reduce the duration of antibiotic therapy, and to assess the prognosis of CAP and thereby aiming to complement Pneumonia Severity Index ( PSI) and other scores. Aims & Objective: To compare prognostic utility of procalcitonin (PCT) with existing biomarkers [C - reactiv e protein (CRP) and total leukocyte count (TLC)] and clinical risk scores (PSI and CURB - 65). Materials and Methods: Fifty patients diagnosed with CAP were included in this study. B aseline serum PCT was measured, which was then stratified according to four predetermined tiers (tier I: <0.1; tier II: 0.1 to <0.25; tier III: 0.25 to <0.5; tier IV: ≥0.5 μg/L). To calculate the severity of pneumonia, patients were classified according to PCT tier, PSI, and CURB - 65 scores. Follow - up PCT and reclassification of PS I and CURB - 65 were carried out on days 4 and 30. Results: PCT was more significantly associated with positive bacterial culture than CRP and TLC. Initial PCT level was significantly correlated with TLC ( p = 0.044), CRP ( p < 0.001), PSI ( p < 0.001), and CUR B - 65 ( p = 0.028). Conclusion: Findings in our study showed that the management of severe CAP would be greatly improved if it were possible to identify, early in the course of disease, those patients who are most likely to develop complications and are at the risk of mortality
Authors and Affiliations
Sudhir Agarwal, Manoj Meena, Arvind Misra, Lalit Meena, Mrityunjaya Singh
Keywords
Related Articles
- EP ID EP90768
- DOI 10.5455/njppp.2015.5.120720141
- Views 113
- Downloads 0
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