A Study to Compare the Efficacy of Ondansetron and Palonosetron for Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 10
Abstract
BACKGROUND: This study was undertaken to compare the efficacy and safety of palonosetron and ondansetron for prevention of postoperative nausea and vomiting . Materials and Methods: A total of 100 patients ASA grade I & II between 18-65 years of age , were randomly assigned into one of the two groups, containing 50 patients each.. Group palonosetron received palonosetron .075mg i.v. and Group ondansetron received ondansetron 8mg i.v. The incidence of nausea, retching and vomiting, VAS score for severity of nausea, requirement of rescue antiemetics and adverse effects were evaluated during the first 24hr following end of surgery. RESULTS: The incidence of nausea was significantly lower in the palonosetron group (12%) compared to ondansetron group (30%). Patients requiring rescue antiemetics was significantly lower in the palonosetron group (18%) compared to ondansetron (40%).The PONV score was also significantly lower in the group palanosteron (28%) as compared to ondansetron (52%). Conclusion: The incidence of nausea was significantly lower in the palonosetron group, a lesser need for rescue antiemetic postoperatively and more patients in palonosetron group had a complete response.
Authors and Affiliations
DR. AMIT DAHIYA, DR. ANIL GUPTA, DR. KESHAV CHATURVEDI
Keywords
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