A study to find correlation of Vitamin D level with Disease Activity Measured by DAS 28 Score In Rheumatoid Arthritis Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction: Rheumatoid arthritis is an immune-mediated disease, mainly driven by Th1 cells. Prevalence of RA is approximately 0.8% of population (range 0.13-1.2%). Overall prevalence of RA is three times higher in women than in men Vitamin D may have a role in Rheumatoid arthritis because it suppresses Th1 cells which are a part of adaptive immunity. Data obtained from animal models show that the VDR ligand along with other factors may control the development of RA 5 .Due to possible role of vitamin D in development of RA and its severity, we conducted this study to find out correlation between rheumatoid arthritis disease activity and serum Vitamin D level .Material and methods: Hospital based case control type of analytical study of 80 cases of Rheumatoid arthritis and 80 controls studied based on detailed history, examination, blood investigations,DAS 28 score.Results: In our study there was significant negative correlation between disease activity measured by DAS-28 in RA and serum 25(OH) Vitamin D level (p<0.05) Conclusion: The result of our study showed that In Rheumatoid arthritis, disease activity measured by DAS-28 is inversely related to Vitamin D level. So timely vitamin d supplementation to patients can reduce inflammatory burden.
Authors and Affiliations
Dr. Dharam. P. Bansal, Dr. Pradeep Kumar sharma, Dr. Venus Sharma, Dr. Arpit Pareek, Dr. Piyush
Keywords
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- EP ID EP554068
- DOI 10.9790/0853-1803027380.
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