A study to find correlation of Vitamin D level with Disease Activity Measured by DAS 28 Score In Rheumatoid Arthritis Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction: Rheumatoid arthritis is an immune-mediated disease, mainly driven by Th1 cells. Prevalence of RA is approximately 0.8% of population (range 0.13-1.2%). Overall prevalence of RA is three times higher in women than in men Vitamin D may have a role in Rheumatoid arthritis because it suppresses Th1 cells which are a part of adaptive immunity. Data obtained from animal models show that the VDR ligand along with other factors may control the development of RA 5 .Due to possible role of vitamin D in development of RA and its severity, we conducted this study to find out correlation between rheumatoid arthritis disease activity and serum Vitamin D level .Material and methods: Hospital based case control type of analytical study of 80 cases of Rheumatoid arthritis and 80 controls studied based on detailed history, examination, blood investigations,DAS 28 score.Results: In our study there was significant negative correlation between disease activity measured by DAS-28 in RA and serum 25(OH) Vitamin D level (p<0.05) Conclusion: The result of our study showed that In Rheumatoid arthritis, disease activity measured by DAS-28 is inversely related to Vitamin D level. So timely vitamin d supplementation to patients can reduce inflammatory burden.
Authors and Affiliations
Dr. Dharam. P. Bansal, Dr. Pradeep Kumar sharma, Dr. Venus Sharma, Dr. Arpit Pareek, Dr. Piyush
Keywords
Related Articles
- EP ID EP554068
- DOI 10.9790/0853-1803027380.
- Views 38
- Downloads 0
Gartner’s Cyst During Pregnancy Presenting As Acute Emergency : A Case Report
Gartner’s duct cysts are remnants of Wolffian duct usually located in the anterolateral wall of vagina and may be associated with renal and ureteral anomalies. This is a case report of a 19 year old primi at 25 weeks ofg...
Impact of Cigarette Smoking On Lipid Profile among South Indian Smokers.
Tobacco smoking is one of the well known modifiable risk factors for atherosclerosis, coronary heart diseases, lung & oral cancers and chronic obstructive pulmonary diseases. Tobacco is consumed in many ways such as chew...
A Post Marketing Surveillance Study To Evaluate The Safety Of Abhayrab Vaccine, A Purified Vero Cell Rabies Vaccine Manufactured Byhuman Biologicals Institute, When Administered By Intradermalroute In Category Iianimal Exposure Subjects In India.
Background:Rabies is a viral disease which is almost always fatal. It is a neglected zoonotic disease which still causes significant mortality, mostly in the developing and third world countries. The mainstay in preventi...
Maxillary Central Incisor with Four Root Canals: A Rare Case Report.
Knowledge of dental anatomy and its variations is a pre-requisite for successful endodontic treatment. Abnormal variations in canal morphology may present a challenge to the practitioner. The occurrence of 4 canals in th...
Vaginal Delivery in Maternal Cyanotic Congenital Heart Disease-Transposition of Great Arteries
Transposition of great arteries(TGA) is the most common cyanotic congenital heart disease(CHD). Pregnancy induces hemodynamic changes which in women with CHD, can endanger mother and child. We had two cases of TGA, one h...