A System and Method for Non-Invasive Measurement of Cardiovascular Blood Pressure
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 7, Issue 2
Abstract
A system and method for the non-invasive portable ultrasound-based measurement system of the Cardiovascular blood pressure is presented, wherein the blood pressure measurement model is calibrated to the simultaneous direct measurements by pressure transducers during the catheterization. The model is based on the image time series processing estimating the changes of the oscillating traceable regions via the introduction of the new ultrasound generalized M-Mode and the notion of the derived image. Once calibrated the system is ready to recalculate the pressure in the calibrated region, such as Left Atrium according to the subsequent non-invasive ultrasound measurements. The system has been successfully tested on animals (sheep) under subsequent catheterisations. Diseases including CHF is a major cause of premature death: according to the American Heart Association, one in 8 deaths has CHF mentioned on the death [1]. Measuring PAP and LAP (or its proxy PCWP) directly helps to predict CHF as pulmonary hypertension is a major chronic disease associated with CHF [2]. LAP could serve as marker for left ventricle diastolic dysfunction, which is highly connected to heart failure, if it would not be shown that it is not exactly equivalent to Left Ventricular End Diastolic Pressure (LVEDP) [3]. Currently used implantable devices allow home environment measurements and can provide reliable pressure (mainly PAP), but their usage is limited and requires at least the catheterization. The last is an invasive procedure but should not necessarily result in any implantations or on the contrary can serve for Pacemaker or Occluder devices implantations. The proposed system and method utilise any catheterization procedure and allow home environment measurements and monitoring of the CHF susceptible patients. The current approach is based on the synchronized simultaneous measurements of the ICP with the micro-manometer catheters (pressure transducers) and US recordings with the subsequent signal and image processing. The animal trials were carried out under the approval of the Helsinki research ethics committee: during the first catheterization of each 7 months’ age lamb (50- 60kg) a device was implanted into the inter-atrial septum: one sheep has got AFR (from Occlutech International AB) having balltipped 3mm width 15mm length nitinol plate (Figure 1a), second – same size regular AFR (Figure 1b) and the third - Occlutech Figulla Flex II PFO occluder (Figure 1c). Every device implantation was proceeding under fluoroscopy and intra-cardiac echocardiography (ICE). The ICP was measured on device implantation and then after 3 and 6 months. At each procedure the sheep was anesthetized and breathed with the lung ventilation machine. LA, RA, LV, RV, PA and PAW pressures were measured by catheters simultaneously with US from the left side of lamb’s chest. The final catheterizations additionally contained the measurements under Phenylephrine/ Adrenaline injections to increase ICPs. The overall scheme of the calibration system is shown in (Figure 2).
Authors and Affiliations
Alexander Brenner, Felix Brenner, Yuri Brodsky, David Fiks, Sergey Yusimov, Avraham Lorber
Keywords
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- EP ID EP592701
- DOI 10.26717/BJSTR.2018.07.001466
- Views 191
- Downloads 0
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