A SYSTEMATIC REVIEW ON ANGINA - FOCUSING NITRATES AND NEED OF NEWER AGENTS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
Angina is a known symptom for a complicated cardiovascular disease i.e, Ischemic Heart disease. It occurs when there is a mismatch of oxygen demand and supply to myocardium. To cater it, drugs from β blockers, Calcium Channel Blockers, organic nitrates and few newer agents are used. For more than a century, the drug of choice has been nitroglycerin. By the end of 19th century, a phenomenon Nitrate tolerance was observed in individuals consuming nitrate sustain therapy or as a prophylactic agent. Various mechanisms have been proposed in different articles for nitrate tolerance which include compromised biotransformation and also increased oxidative stress. It is one of the reason which limited the clinical efficacy of nitrates in angina. Nowadays newer agents with different mechanism of action are introduced like Ivabradine, Ranolazine, Trimetazidineand Nicorandil which will be discussed in this review in detail in terms of their efficacy in improving individual’s health and quality of life.
Authors and Affiliations
Afshan Siddiq
Keywords
Related Articles
- EP ID EP667759
- DOI -
- Views 161
- Downloads 0
BURDEN OF CEREBRAL MALARIA; PERSONALIZED MEDICINE TO THE RESCUE: A REVIEW OF THE NEW CONCEPT
Malaria is endemic in over 100 countries and about 240 million people are at risk of developing the disease. Annually, about 20-30 million clinical malaria cases occur globally with over 1 million deaths. In 2017 alone,...
ANTIOXIDANTS EFFECTS IN CANCER SURVIVORS: A SHORT PERSPECTIVE
There have been intense debates on the use of antioxidants as neoadjuvant therapy or in combination with anti-cancer agents in the treatment of human malignancies. While the safety and effectiveness of commonly used diet...
UNDERNUTRITION AND ASSOCIATED RISK FACTORS AMONG PRESCHOOL AGE CHILDREN IN EVODOULA HEALTH DISTRICT, CENTRAL REGION OF CAMEROON
Background: Limited information is available on the risk factors associated with preschool child undernutrition in Cameroon. This study describes the prevalence of stunting, wasting and underweight and their associated f...
ROLE OF DIET IN PCOS (LIFE STYLE DISORDER)
Diseases of longevity often referred as "lifestyle disorders" is a great threat to the overall health of the society. Pcos patients are not always obese but PCOS is mainly associated with obesity and insulin resistance....
UNDERSTANDING GRAHANI THROUGH GUT AND BRAIN RELATION & IT’S MANAGEMENT “GRAHANI AND BRAIN”
Irritable Bowel Syndrome (IBS) is one of several highly prevalent, multi-symptom gastrointestinal motility disorders that have a wide clinical spectrum and is one of the most common conditions encountered in clinical pra...