A Systematic Study on Processing Problems and In-vitro Release of Saraca indica Caesalpiniaceae Bark Powder Tablets

Journal Title: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH - Year 2012, Vol 11, Issue 3

Abstract

Purpose: To examine the original flowability, compressibility and compactibility of Saraca indica bark powder and its tablet formulations. Methods: Saraca indica bark powder was subjected to various quantitative tests including acid insoluble ash, total ash, foreign organic matter, alcohol soluble extractive and water soluble extractive. Its flowability and compressibility were determined using Kawakita, Heckel and Leuenberger relationships. Tablets were prepared from the powder by direct compression and wet granulation techniques and characterized. Results: Kawakita analysis revealed lower cohesiveness of granules (3.877 ± 0.890) compared to the powder (6.176 ± 1.030), and hence improved flowability. From Heckel analysis, the higher value of intercept (A) for granules (4.38 ± 0.45) implies higher degree of fragmentation than direct compression DC formulation (2.90 ± 0.33) and powders (2.44 ± 0.12). The compression susceptibility parameter obtained from Leuenberger equation for compacts formed by wet granulation technique (0.183 ± 0.045 1/kg/cm2) indicate that maximum crushing strength is reached faster at lower pressures of compression than for Saraca indica bark powder (0.073 ± 0.025 1/kg/cm2) and DC formulation (0.105 ± 0.033 1/kg/cm2). In-vitro dissolution study showed that more than a 90% of tannin was released within 30 and 60 min from tablets prepared by wet granulation and DC, respectively. Brittle fracture index data indicate that tablets prepared from granules showed less fracture, capping and lamination tendencies. Conclusion: It is concluded that the desired flowability, compressibility and compactibility of Saraca indica bark powder can be obtained by direct compression and wet granulation techniques.

Authors and Affiliations

Satya Prakash Singh , Ch Niranjan Patra , Subas Chandra Dinda

Keywords

Related Articles

Antimicrobial effects of Indian medicinal plants against acne-inducing bacteria

Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Indian medic...

Studies on Wound Healing Properties of Quercus infectoria

Purpose: The aim of the present study was to investigate the wound healing activity of the selected Indian medicinal plant Quercus infectoria. Method: Ethanol extract of the shade-dried leaves of Quercus infectoria was...

A Systematic Study on Processing Problems and In-vitro Release of Saraca indica Caesalpiniaceae Bark Powder Tablets

Purpose: To examine the original flowability, compressibility and compactibility of Saraca indica bark powder and its tablet formulations. Methods: Saraca indica bark powder was subjected to various quantitative tests...

Download PDF file
  • EP ID EP119798
  • DOI http://dx.doi.org/10.4314/tjpr.v11i3.7
  • Views 130
  • Downloads 0

How To Cite

Satya Prakash Singh, Ch Niranjan Patra, Subas Chandra Dinda (2012). A Systematic Study on Processing Problems and In-vitro Release of Saraca indica Caesalpiniaceae Bark Powder Tablets . TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 11(3), 387-395. https://europub.co.uk/articles/-A-119798