A SYSTEMIC REVIEW ON FLOATING MUCOADHESIVE DRUG DELIVERY SYSTEM
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity.The floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. Thus, floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. In this regard, this review aims to provide information of different floating and mucoadhesive approaches and their importance. Keywords: Bioadhesive, floating drug delivery, gastroretentive, mucoadhesive
CHEMICAL CONSTITUENTS AND MEDICAL IMPORTANCE OF GALIUM APARINE - A REVIEW
The phytochemical screening of extracts of Galium aparine revealed that the plant contained phenols, tannins, alkaloids, anthraquinones, coumarins, iridoids asperuloside, alkanes, flavonoids and saponins. Previous pharma...
PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF HELIOTROPIUM UNDULATUM [H. BACCIFERUM] AND HELIOTROPIUM EUROPAEUM- A REVIEW
The phytochemical analysis of Heliotropium undulatum [Heliotropium bacciferum] revealed the presence of alkaloids, saponins, tannins, steroids, terpenoids, flavonoids, glycosides, and phenols. While, Heliotropium europae...
A REVIEW ON FAST DISSOLVING TABLETS
Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researchers developed the fast dissolving tablet (FDT) with impr...
INVITRO ANTIHELMINTHIC ACTIVITY OF RAUWOLFIA SERPENTINA ON PHERETIMA POSTHUMA
Antihelmintics are the drugs used to eradicate or reside the number of helmintic parasites from intestinal tract or tissue of humans and other animals. The antihelmintic activity of Rauwolfia serpentina root extracts wer...
NON-ADHERENCE IN HYPPERTENSIVE PATIENTS OF PESHAWAR, PAKISTAN
Introduction: Hypertension is a major risk factor for cardiovascular morbidity and mortality. Adherence to antihypertensive treatment plays an important role in controlling hypertension and reducing mortality and morbidi...