A Technical Review On Hyperthermia
Journal Title: International Journal of Scientific Research and Management - Year 2015, Vol 3, Issue 6
Abstract
Hyperthermia has promising strategy to enhance apoptosis .The fundamental idea and the effects of heat on cancer cells are well known. However, the results obtained in therapy by hyperthermia (HT) alone have been only partially satisfactory. Treatment at temperatures b etween 40 and 44 ° C is cytotoxic for cells in an environment with a low oxygen partial pressure and low pH, conditions that are found specifically within tumour tissues, due to insufficient blood perfusion. Under such conditions radiotherapy is less effect ive, and systemically applied cytotoxic agents will reach such areas in lower concentration than in well - per fused areas. Therefore, clinically it is preferred to use hyperthermia in combination with radiation therapy and chemotherapy. Hyperthermia can be applied by several methods: local hyperthermia by external or internal energy sources; regional hyperthermia by perfusion of organs or limbs or by irrigation of body cavities; and whole body hyperthermia. Which can be implemented by many heating methods, s uch as microwave, radiofrequency, laser and ultrasound. Number of studies have reported the combination of thermo - radiotherapy. Fortunately, phase II, III clinical trials have demonstrated that hyperthermia combination therapy is beneficial for local tumo ur control and survival in patients with high - risk tumours of different types. Consequently, much attention has been focussed on identifying agents among the conventional chemotherapeutics substances that can sensitise tumour cells to hyperthermia - induced damage with minimal effects on normal cells. In the review, we overviewed important mechanism of hyperthermia - induced apoptosis and the substance which can act as heat sensitizers’ in cancer therapy.
Authors and Affiliations
D. Kaarthika
Keywords
Related Articles
- EP ID EP216906
- DOI -
- Views 72
- Downloads 0
Computer Science and Software Engineering
Network Security i s the most vital component in information security because it is responsible for securing all information passed through networked computers. Network Security refers to all hardware and...
Global Syst em For Mobile Communication (GSM )
Global system for mobile communication (GSM) is universally accepted standard for digital cellular communication. GSM is the name of a calibration group established in 1982 to create a common European mobile telepho...
Detection of Field Defects in Primary Open Angle Glaucoma Patients Using Humphrey’s Automated Perimetry – Clinical Study
G l a u c o m a i s pr o g res s i v e, chr o n i c op t i c ne u r opa t hy c h aract e r i zed by ac q u i red atro p hy o f op t i c n e r v e a n d l o s s of re t i n a l g a ngli o n ce l l s a n d a x o n s. Tod a...
Understanding the Revenue Structure of Municipalities in the Context of Achieving Sustainable Development
In general, the main issue that all municipalities seek in scope of revenue is creating a systemized and integrated structure that can lead to gaining sustainable earning for municipality. New attitude of urban managemen...
The Role o f Compensation t o Work Satisfa ction a nd Employee Performance o f Steel Fabricator Companies i n East Java
This study explains the relationship between compensation to job satisfaction and employee performance of steel fabricator company in East Java. Data were obtained in this study from a sample of 170 employees of the oper...