A Technical Review On Hyperthermia
Journal Title: International Journal of Scientific Research and Management - Year 2015, Vol 3, Issue 6
Abstract
Hyperthermia has promising strategy to enhance apoptosis .The fundamental idea and the effects of heat on cancer cells are well known. However, the results obtained in therapy by hyperthermia (HT) alone have been only partially satisfactory. Treatment at temperatures b etween 40 and 44 ° C is cytotoxic for cells in an environment with a low oxygen partial pressure and low pH, conditions that are found specifically within tumour tissues, due to insufficient blood perfusion. Under such conditions radiotherapy is less effect ive, and systemically applied cytotoxic agents will reach such areas in lower concentration than in well - per fused areas. Therefore, clinically it is preferred to use hyperthermia in combination with radiation therapy and chemotherapy. Hyperthermia can be applied by several methods: local hyperthermia by external or internal energy sources; regional hyperthermia by perfusion of organs or limbs or by irrigation of body cavities; and whole body hyperthermia. Which can be implemented by many heating methods, s uch as microwave, radiofrequency, laser and ultrasound. Number of studies have reported the combination of thermo - radiotherapy. Fortunately, phase II, III clinical trials have demonstrated that hyperthermia combination therapy is beneficial for local tumo ur control and survival in patients with high - risk tumours of different types. Consequently, much attention has been focussed on identifying agents among the conventional chemotherapeutics substances that can sensitise tumour cells to hyperthermia - induced damage with minimal effects on normal cells. In the review, we overviewed important mechanism of hyperthermia - induced apoptosis and the substance which can act as heat sensitizers’ in cancer therapy.
Authors and Affiliations
D. Kaarthika
Keywords
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