A trend of antibiotic resistance pattern of klebsiella pneumoniae isolated from various clinical samples in patients attending tertiary care hospital Saurashtra region, Gujarat, India
Journal Title: Medpulse International Journal of Microbiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Klebsiella pneumoniae has been associated with different types of infections and one of the most important aspects of Klebsiella pneumoniae is emergence of multi-drug resistant strains. Moreover, extensive use ofbroad-spectrum antibiotics in hospitalized patients has led to both increased carriage of Klebsiella and the development of multidrug-resistant strains that produce extended-spectrum beta-lactamase (ESBL)Aims and Objectives:To know the prevalence of klebsiella pneumoniae infection. To know the trend of drug resistance pattern of Klebsiella pneumoniae isolates.To promote rational use of medicines to avoid antibiotic drug resistance.Materials and Methods: Out of35024total samples 2617 Klebsiella pneumoniae were isolated from various samples (blood, pus, sputum, urine) which were identified by phenotypic methods (Gram’s stain, colony morphology, biochemical reactions) from 2011-2014 were included in this study. These isolates were tested for antimicrobial drug sensitivity pattern by modified Kirby-Bauer disc diffusion method according to CLSI guideline.Results: Out of 35024 samples 2617 Klebsiella pneumoniae isolates were confirmed.1001 were isolated from blood culture, 775 were from pus, 533 were from urine and 308 were from sputum. As per our statistical data, 50% of isolates were multi-drug resistant. In antibiogran pattern, we found that most isolates were resistant to Ampicillin and Cephalothin; Gentamicin and Ceftazidime were moderately resistant and Piperacillin-tazobactum was least resistant.Conclusion:Our study concludes that there is overall increase in infection due to klebsiella pneumoniae strain and there is gradual increase in resistant klebsiella pneumoniae strain from the year 2011 to 2014.We strongly recommend that establish systems for monitoring antimicrobial resistance in hospitals to prepare treatment guideline policy.for pus samples; 66.67% in 2008, 61.11% in 2009 and 56.92% in 2010 for sputum samples and 78.31% in 2008, 74.44% in 2009 and 71.60% in 2010 for urine samples
Authors and Affiliations
Chintan Dalwadi, Hitesh Ahir
Keywords
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- EP ID EP616972
- DOI 10.26611/10081023
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