A work on synthesis & characterization of Piperidine-4-carbohydrazide derivatives with its antimicrobial evaluation of pharmaceutical interest.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 3
Abstract
A series of piperidine-4-carboxylic acid methyl ester coupled with N-phthaloyl amino acids derivatives were synthesized, characterized and their antimicrobial properties were evaluated. These compounds were synthesized with dicyclohexylcarbodimide coupling of piperidine-4-carboxylic acid methyl ester with N-phthaloyl amino acids with N, N'-dicyclohexylcarbodiimide followed by ring opening reaction with cyclopropylamine and reaction of ester with hydrazine hydrate to obtain final compound characterized using IR, 1H and 13C-NMR and mass spectroscopy. The synthesized compounds were screened for their in vitro antimicrobial activity against S. aurous, E. coli, P. aeruginosa, S. typhimurium, F. oxysporum and A. alternate. Some of these compounds exhibited moderate to good activity, where as some were inactive
Authors and Affiliations
Paresh Shende
Keywords
Related Articles
- EP ID EP408549
- DOI -
- Views 124
- Downloads 0
Aerobic Exercises: To trim down menstrual distress among adolescent girls
Menstrual distress is a hindrance that curtails the quality of life, especially among the adolescent period where the effects are at its peak which resolves as they ovulate progressively. The purpose is to reduce the me...
Prediction of target enzyme for diabetes mellitus by isolated blood samples
Diabetes Mellitus is a serious problem universally, by and large in both developing as well as underdeveloped nations. Conversely, a synthetic drug management of diabetes mellitus creates an unexpected adverse effect tow...
Effect of topical tazoretene in comparison to topical corticosteroids on serum proteins in chronic plaque psoriasis
Tazarotene, the first of new generation receptor selective topical retinoid, currently being investigated and widely used in treatment of mild to moderate psoriasis. Objective: Effect of topical tazoretene in comparison...
Assess the factors influencing suicidal behavior among school students
The word “suicide” has its origin in Latin; sui’, of one self and “caedere”, to kill: the act of internationally destroying Once life. The phenomenon of suicide has at all times attracted the attention of moralists, soci...
Role of allopurinol as an oxygen free radical scavanger in prevention of ischemic reperfusion myocardial injury in albino rabbits
Aim: To study the role of allopurinol as an oxygen free radical scavenger, in prevention of myocardial ischemic reperfusion injury in albino rabbits. Materials and Methods Albino Rabbits of either sex were divided into t...