Abdominal hernia repair surgery with the new injectable polymer biomaterials
Journal Title: New Medicine - Year 2015, Vol 19, Issue 2
Abstract
Introduction. The new injectable polymer biomaterials offer a completely innovative approach to hernia repair surgery. This study evaluated the potential application of injectable polymer biomaterials in hernia treatment using an animal model. Local connective tissue reactions associated with the new injectable polymer biomaterials were compared with the reactions provoked by commercial polypropylene mesh. Aim. Evaluation of the potential application of injectable pol¬ymer biomaterials in the treatment of abdominal wall hernias using an animal model. Material and methods. Five groups of rabbits with previously-created hernias were treated with new biomaterials injected in nonpolymerized form into hernial openings. The same animals had previously polymerized discs surgically implanted in the dorsal subcutaneous area. The rabbits were kept under clinical observation for 28 days, then sacrificed under anesthesia. Samples of subcutaneous tissue were taken from the hernia region and from the vicinity of the polymerized biomaterial discs implanted in the dorsal area for histological examination. Results. In groups 1, 2 and 3, hernia treatment results, laboratory tests and histological examination of the tissues previously taken from the operated hernia sites were similar to the results obtained in the control group. In groups 1, 2 and 3, the numbers of fibrocytes and neutrophils in the vicinity of the subcutaneously-implanted discs in the dorsal area were similar to those in the hernial region treated with mesh in the control group. Conclusions. Biomaterials 188-UR /PEG -DA 85/15, P1838-DM A and 1838_UR can be used in animals in the near future as possible abdominal wall hernia treatments. These biomaterials were as efficient as the polypropylene mesh used in the control group for treating abdominal wall hernias.
Authors and Affiliations
Labib Zair, Jędrzej Skrobot, Mariola Marchlewicz, Jarosław Lichota, Leonard Gugała, Magdalena Kuczyńska, Samir Zeair, Ewa Duchnik, Karol Tejchman, Barbara Wiszniewska, Jerzy Sieńko, Tadeusz Sulikowski, Marek Ostrowski, Mirosława El Fray
Keywords
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- EP ID EP79597
- DOI 10.5604/14270994.1169773
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