The aim of the study was to assess the level of calpain and its endogenous substrates – microtubule-associated protein 2 (MAP-2) and fodrin in the rodent model of global cerebral ischaemia caused by temporary cardiac arr...
We report a 18-year-old female patient with livedo reticularis and neurological disturbances. CT scan showed two big ischemic focuses in the pons, moreover MRI revealed small disseminated ischemic focuses in the pons and...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that can be acquired either by direct transmission, inherited through dominant mutations in the prion protein gene o...
The glial cells play an important role in pathophysiology of the intracerebral haemorrhage (ICH). Thus the attempt at evaluating the possible influence of the propofol on the reactivity of astro- and microglial cells i...
Since the earliest descriptions, senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the pathological hallmarks of Alzheimer’s disease (AD). Consequently, studies of the morphology, distribution...
Changes of cytoskeletal proteins in ischaemic brain under cardiac arrest and reperfusion conditions
The aim of the study was to assess the level of calpain and its endogenous substrates – microtubule-associated protein 2 (MAP-2) and fodrin in the rodent model of global cerebral ischaemia caused by temporary cardiac arr...
Sneddon‘s syndrome as a disorder of small arteries with endothelial cells proliferation: ultrastructural and neuroimaging study
We report a 18-year-old female patient with livedo reticularis and neurological disturbances. CT scan showed two big ischemic focuses in the pons, moreover MRI revealed small disseminated ischemic focuses in the pons and...
Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that can be acquired either by direct transmission, inherited through dominant mutations in the prion protein gene o...
The effect of propofol on astro- and microglial reactivity in the course of experimental intracerebral haemorrhage in rats
The glial cells play an important role in pathophysiology of the intracerebral haemorrhage (ICH). Thus the attempt at evaluating the possible influence of the propofol on the reactivity of astro- and microglial cells i...
Plaques and tangles and the pathogenesis of Alzheimer’s disease
Since the earliest descriptions, senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the pathological hallmarks of Alzheimer’s disease (AD). Consequently, studies of the morphology, distribution...