Acción del antiveneno botrópico polivalente sobre las actividades proteolíticas presentes en los venenos de serpientes peruanas
Journal Title: Revista Peruana de Medicina Experimental y Salud Publica - Year 2008, Vol 25, Issue 2
Abstract
Peruvian snake venoms responsible for most of ophidism accidents, contain proteolytic enzymes that can degrade tissue and plasmatic proteins, as well as cause hypotension and blood coagulation. [b]Objectives. [/b]The inhibiting capacity of liquid polyvalent bothropic antivenom produced by Instituto Nacional de Salud (INS), has been evaluated on caseinolytic, coagulant and amidolytic activities on Bothrops atrox, Bothrops brazili, [i]Bothrops pictus[/i] and [i]Bothrops barnetti [/i]venoms. [b][i]Material and methods.[/i][/b] Using in each case casein, bovine fibrinogen and the chromogenic substrate BApNA respectively, measuring changes in values of enzymatic activity at ½, 1 and 2 doses of either natural and heating (incubated at 37 °C during five days) antivenom. [b][i]Results. [/i][/b]Caseinolytic activity is more resistant to inhibition especially by the natural antivenom, amidolytic activity was severely inhibited mainly in [i]B. pictus[/i] and [i]B. atrox [/i]venoms. Also coagulant activity was totally inhibited in [i]B. pictus[/i] venom, being high on [i]B. brazili [/i]and [i]B. atrox [/i]venoms. For coagulant and amidolytic activities, heated antivenom was less effective than natural one. [b][i]Conclusions. [/i][/b]The bothropic antivenom produced by INS is effective to inhibit the proteolytic activity from Peruvian snake venoms tested.
Authors and Affiliations
Armando Yarlequé, Dan Vivas, Rosío Inga, Edith Rodríguez, Gustavo Sandoval, Silvia Pessah, César Bonilla
Keywords
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