ACE Gene I/D Polymorphism-A Global Perspective in relation to Indian Population
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 1
Abstract
Alu elements are a family of interspersed repeats in the human genome. Alu ACE insertion (I)/deletion (D) polymorphism is a marker useful to study the genomic diversity of worldwide population. The genomic diversity among the populations may help to understand the evolutionary and migrational history of population. The present investigation is to examine the allele and genotype frequency of three population of south India- Paliyar tribe, Nadar and Pallar. Accurately, 147 samples were collected and genotype was done using PCR-SSP. According to Hardy-Weinberg equilibrium equation, there have no significant difference in Pallar and Nadar population whereas, significant difference was observed in Paliyar tribe population (p-0.0001). The results of phylogenetic tree analysis and PCA showed that south Indian Paliyar tribal population separated from other population in India. It might be due to under selection pressure.
Authors and Affiliations
Sheebanancy K, Maheswari C, Usha Raja Nanthini A
Keywords
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