Acid Phosphatase Activity Of Albino Rats Administered With Salt And Water Samples From Okposi And Uburu Salt Lakes
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2016, Vol 10, Issue 2
Abstract
Water and salt samples from Okposi and Uburu salt lakes have been reported to elicit some toxic properties. This research was set up to study the effect of water and salt samples from Okposi and Uburu salt lakes on the prostate in albino rats. Forty five albino rats, placed in nine groups (A-I) of five rats in each, were used for this research. The animals in groups A and B were treated with 1.5 and respectively of water from Uburu lake, while C and D were given 1.5 and 3.0ml/kg body weight respectively of water from Okposi lake. Groups E and F received 100 and 200mg/kg body weight respectively of salt solution from Okposi lake, and G and H were given 100 and 200mg/kg body weight respectively of salt solution from Uburu lake, while group I was the control. Administration was done orally for seven consecutive days. Average body weight, physical activities, feed and water intake decreased in all the treated groups relative to the control. Total protein concentrations of the groups administered with the samples were found to be significantly lower (P< 0.05) than the values obtained in the control animals. The acid phosphatase activity in the test groups was significantly higher (P<0.05) than in the control. The difference in the levels of these parameters between groups given Okposi sample and Uburu samples was not significant (P>0.05). The difference between the results from the groups treated with water samples and those given salt samples was significant (P>0.05). The effects of all the treatments were found to be dose-dependent. These results suggest that water and salt samples from Okposi and Uburu lake maybe toxic, and this toxicity may be reduced by the method of processing the lakes water into salt.
Authors and Affiliations
Agbafor KN| Biochemistry Dept., Ebonyi State University, Abakaliki, Nigeria. email: kagbafor@yahoo.co.uk
Keywords
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