Acinetobacter spp. an Emerging Pathogen of Septicemia in a Tertiary Care Hospital
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 6
Abstract
Introduction: Bloodstream infections are an important cause of patients serious morbidity and mortality worldwide. Changing bacterial flora and emergence of resistant strains further aggravate the problem. Acinetobacter spp. has emerged as an important pathogen. Multidrug-resistant (MDR) Acinetobacter has become a global threat to the seriously infected patients who critically rely on antibiotic therapy. Carbapenems remain the treatment of choice if isolates are susceptibility to this antimicrobial class. Carbapenem-resistant Acinetobacter isolates are increasingly reported worldwide. MDR of Acinetobacter increasingly jeopardizes the health-care setting, and this is leading to substantial mortality and morbidity globally. The Centers for Disease Control and Prevention considers Acinetobacter a “serious” threat. Methods: The study was done from September 2014 to August 2015. Blood culture of 1073 samples was processed, of which 374 were positive. The tests were done in the microbiology laboratory of the institution. Blood specimens were collected aseptically into Bactec blood culture bottles. Identification of Acinetobacter species was made on the basis of phenotypic criteria. Antimicrobial susceptibility was done using the disc diffusion method (modified Kirby-Bauer test). Results: Acinetobacter spp. was isolated in 41 (10.96%) cases, of which Acinetobacter baumannii was isolated in 24 cases (58.54%), Acinetobacter lwoffii was isolated in 17 cases (41.46%). In the present study, Acinetobacter spp. is sensitivity pattern to antibiotics are as follows: Imipenem was sensitive in 33 (80.48%) cases, meropenem was sensitive in 35 (85.36%), levofloxacin in 25 (62.50%) cases, and ofloxacin was sensitive in 22 (53.65%) cases. Polymyxin and tigecycline were sensitive in all cases of Acinetobacter septicemia. Conclusion: Acinetobacter spp. is emerging as an important pathogen and developing drug resistance. Health education to be provided to the public on the dangers of indiscriminate use of antibiotics. Rational antibiotic use along with implementation of infection control policies are required for control of such infections.
Authors and Affiliations
Sumit Kumar, Sudhir Singh, Umar Farooq, Pallavi Kumari
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