Acquired Pelger-Huet Anomaly and Altered morphology of neutrophils-in vivo Cytotoxicity in patients of sickle cell anaemia treated with hydroxyurea
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 4
Abstract
Objectives & AIMS: The evaluation and identify new prognostic markers suggested in recent studies. Evaluate the relationship between morphological changes in neutrophils and sickle cell anaemia treated with hydroxyurea . mortality morbidity after the initial of dimorphisms changes in neutrophils . Increased and decrease nuclear lobulation in neutrophils as a prognostic value associated with adverse outcomes. We studied the association between pelger huet anomaly during hospital course with hydroxyl urea outcomes survival index of patients. Identify the haematological manifestations (Peripheral smear) of altered haematopoiesis resulting from cytotoxicity of dna damage due to hydroxyl urea .Review the pathogenesis of the haematological manifestations of hydroxylurea. Material & Methods: Blood was collected in a sterile EDTA containing tube and processed following our established iso certified hospital based laboratory protocol .A complete blood counting including HB%,PCV, Red cell indices ,platelet count, total white cell count done by Automated blood cell counter. The all cell count indices including RBC, WBC count with differential along with morphological changes further confirmed by manual oil immersion smear study method. Peripheral smears study was done with field A and B stain and leishman stain. Conclusion: This study demonstrates sickle cell anaemia treated with hydroxyurea . mortality morbidity after the initial of dimorphisms changes .This is a cytotoxic effect on the neutrophils of patients with sickle cell anaemia, and Hydroxy urea may even be able to promote a protective effect on these cells, however there is the risk of DNA damage associated with exposure for longer periods of time. The monitoring of patients with sickle cell anaemia is important, since the data on the cytotoxic effective is conclusive.
Authors and Affiliations
Dr. Shailendra Singh Thakur
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- EP ID EP504843
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